| Type | Description |
|---|---|
| Definition | dihydroorotate dehydrogenase (quinone) |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:33:00 | SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation. | 33510132 |
| 2020-10-24 14:08:00 | Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer. | 32151633 |
| 2020-05-30 11:16:00 | These findings implicate DHODH and PCK1 in the colorectal cancer metastatic progression via pyrimidine nucleotide biosynthesis under hypoxia. | 31841108 |
| 2020-04-11 12:45:00 | The authors show that DHODH-driven pyrimidine biosynthesis is an essential pathway linking respiration to tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents. | 30449682 |
| 2020-01-04 10:07:00 | he preliminary structure-activity relationship was investigated. Compound 9 of biphenyl series and compound 37 of amide series displayed IC50 values of 1.32 muM and 1.45 muM, respectively. This research will provide valuable reference for the research of new structures of hDHODH inhibitors | 31370178 |
| Type | IDs |
|---|---|
| Synonymous | DHOdehase, POADS, URA1 |
| Gene |
UniProtKB-ID:
PYRD_HUMAN
UniprotKB:
Q02127
UniParc:
UPI00001FF5FB
EMBL:
AK292293,
BC065245,
M94065
Ensembl:
ENSG00000102967
KO:
hsa:1723
|
| Nucleutide sequences |
EMBL-CDS:
AAH65245.1,
AAA50163.1,
BAF84982.1
Ensembl_TRS:
ENST00000219240
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000219240
RefSeq:
XP_005255886.1,
NP_001352.2,
XP_016878479.1,
XP_005255884.1
|
| Others |
UniRef100:
UniRef100_Q02127
UniRef90:
UniRef90_Q02127
UniRef50:
UniRef50_Q02127
UniGene:
Hs.654427
CCDS:
CCDS42192.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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