| Type | Description |
|---|---|
| Definition | spectrin repeat containing nuclear envelope protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:23:00 | A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss muscular dystrophy. | 32184094 |
| 2020-11-21 13:12:00 | Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle. | 31578382 |
| 2020-01-04 11:49:00 | Results indicate that sperm associated antigen 4 transcript isoform interacts with spectrin repeat containing nuclear envelope protein 2 (Nesprin2) in the meiotic process. | 31144711 |
| 2019-11-30 11:44:00 | CRISPR/Cas9-mediated knockout of Syne-2 in cell culture led to an overexpression and mislocalization of Pcnt and to ciliogenesis defects. This suggests that the Pcnt-Syne-2 complex is important for ciliogenesis and outer segment formation during retinal development and plays a role in nuclear migration. | 30054381 |
| 2019-01-19 11:33:00 | Study shows that modulation of matrix pore size or of lamin A expression known to modulate nuclear stiffness directly impinges on levels of MT1-MMP-mediated pericellular collagenolysis by cancer cells. This response requires an intact connection between the nucleus and the centrosome via the linker of nucleoskeleton and cytoskeleton (LINC) complex protein nesprin-2 and dynein adaptor Lis1. | 29934494 |
| Type | IDs |
|---|---|
| Synonymous | EDMD5, KASH2, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH |
| Gene |
UniProtKB-ID:
SYNE2_HUMAN,
Q6MZP0_HUMAN
UniprotKB:
Q8WXH0,
Q6MZP0
UniParc:
UPI000007012B,
UPI000000D884,
UPI0005A5D025,
UPI0000071855,
UPI000018DB96,
UPI00001AE803,
UPI00001B0452,
UPI00001BDC4C,
UPI00017A77D7,
UPI000000D9C7,
UPI0005A5D029,
UPI00003677E5,
UPI00017A771A,
UPI00000728C5
EMBL:
AY184205,
BC071873,
AK297874,
CD654909,
AK074055,
AF495911,
BC042134,
BX640974,
AY061759,
AY061758,
AF435011,
AB023228,
AL080133,
JQ754367,
AY184204,
AF435010,
AK298465,
AL162832,
AK090430,
AK095241,
BM805144,
AY061757,
AL355094,
AL359235,
AL117404
Ensembl:
ENSG00000054654
KO:
hsa:23224
|
| Nucleutide sequences |
EMBL-CDS:
CAB55905.2,
AAH71873.1,
BAG60199.1,
AAL33801.1,
AAO27772.1,
BAG60678.1,
AAN60443.1,
AAO27773.1,
AAL33547.1,
AAL33802.1,
BAC03411.1,
AAL33800.1,
BAA76855.3,
CAB45729.1,
BAB84881.1,
AFN44385.1,
AAL33548.1,
BAC04506.1,
AAH42134.1,
CAE45988.1
Ensembl_TRS:
ENST00000358025,
ENST00000341472,
ENST00000344113,
ENST00000458046
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000341781,
ENSP00000344528,
ENSP00000391937,
ENSP00000350719
RefSeq:
XP_005267511.1,
XP_005267514.1,
XP_011534877.1,
XP_011534882.1,
NP_878914.1,
XP_011534881.1,
XP_011534880.1,
XP_016876591.1,
XP_005267515.1,
NP_055995.4,
XP_005267513.1,
XP_011534883.1,
XP_011534878.1,
XP_016876593.1,
XP_011534886.1,
NP_878917.1,
XP_016876590.1,
XP_005267516.1,
NP_878918.2,
XP_011534876.1,
XP_011534884.1,
XP_011534879.1,
XP_016876592.1
|
| Others |
UniRef100:
UniRef100_Q8WXH0,
UniRef100_A0A0C4DGK3
UniRef90:
UniRef90_Q8WXH0
UniRef50:
UniRef50_Q8WXH0
UniGene:
Hs.745014
CCDS:
CCDS45125.1,
CCDS45124.1,
CCDS9761.2,
CCDS41963.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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