| Type | Description |
|---|---|
| Definition | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Date | Results | Publications |
|---|---|---|
| 2018-10-06 10:51:00 | ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-mTOR-S6 K1 signaling | 29246230 |
| 2018-04-21 11:20:00 | The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study. | 29042184 |
| 2017-09-23 13:38:00 | Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy | 28267080 |
| 2017-07-01 11:37:00 | The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients. | 27379764 |
| 2016-09-24 10:55:00 | ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events. | 26799664 |
| Type | IDs |
|---|---|
| Synonymous | AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH |
| Gene |
UniProtKB-ID:
PUR9_HUMAN,
V9HWH7_HUMAN
UniprotKB:
P31939,
V9HWH7
UniParc:
UPI000000122D,
UPI000198C741
EMBL:
U37436,
BC008879,
EU794654,
AB062403,
D89976,
CH471063,
D82348,
AK290067,
AC073284
Ensembl:
ENSG00000138363
KO:
hsa:471
|
| Nucleutide sequences |
EMBL-CDS:
AAH08879.1,
BAF82756.1,
AAY24062.1,
AAA97405.1,
BAA11559.1,
EAW70529.1,
BAB93490.1,
BAA21762.1,
ACJ13708.1
Gene_ORFName:
OK/SW-cl.86
Ensembl_TRS:
ENST00000435675,
ENST00000236959
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000236959,
ENSP00000415935
RefSeq:
XP_024308687.1,
XP_016859676.1,
NP_004035.2
|
| Others |
UniRef100:
UniRef100_P31939
UniRef90:
UniRef90_P31939
UniRef50:
UniRef50_P31939
UniGene:
Hs.90280
CCDS:
CCDS2398.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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