| Type | Description |
|---|---|
| Definition | single-strand-selective monofunctional uracil-DNA glycosylase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:26:00 | Role of Arg243 and His239 Residues in the Recognition of Damaged Nucleotides by Human Uracil-DNA Glycosylase SMUG1. | 32571189 |
| 2020-01-25 14:49:00 | Data shows that SMUG1 forms an extensive network of contacts with DNA involving certain amino acids. Phe98 is involved in the stacking interaction in the base-binding pocket of the active site. His239 handles the DNA backbone via a contact with a phosphate group, and Arg243 gets inserted into the void formed after Ura base flipping out from the DNA duplex and forms a network of hydrogen bonds with neighboring nucleobases. | 31466351 |
| 2019-08-24 11:51:00 | Exposure of DNA oligomers with deoxyuridine monophosphate incorporated at a specific site (U-DNA) to hSMUG1 causes strand cleavage at the lesion site, indicating that the enzyme incises DNA after uracil removal. | 30496516 |
| 2018-06-09 12:21:00 | This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype. | 27909884 |
| 2017-12-02 12:23:00 | Our study showed that c.-31A/G-SMUG1 genotypes/alleles do not have any association with the occurrence or severity of advanced type age-related macular degeneration (AMD). There was no interaction of CRP levels and SMUG1 genotypes in AMD susceptibility. | 28095127 |
| Type | IDs |
|---|---|
| Synonymous | FDG, HMUDG, UNG3 |
| Gene |
UniProtKB-ID:
SMUG1_HUMAN,
A0A0S2Z526_HUMAN,
A0A024RAZ8_HUMAN
UniprotKB:
Q53HV7,
A0A0S2Z526,
A0A024RAZ8
UniParc:
UPI0000073EC2,
UPI00000701FC
EMBL:
KU178578,
BC105607,
AK222473,
CH471054,
BC088352,
AK091468,
BC000417,
AF125182,
AK001235,
AK290274,
AF489699,
KU178579
Ensembl:
ENSG00000123415
KO:
hsa:23583
|
| Nucleutide sequences |
EMBL-CDS:
BAD96193.1,
AAI05608.1,
AAH88352.1,
AAH00417.1,
AAD17301.1,
BAA91571.1,
BAC03670.1,
AAL86910.1,
BAF82963.1,
EAW96752.1,
EAW96756.1,
ALQ34036.1,
EAW96753.1,
ALQ34037.1,
EAW96754.1,
EAW96755.1,
EAW96757.1
Gene_ORFName:
hCG_23349
Ensembl_TRS:
ENST00000243112,
ENST00000508394,
ENST00000514685,
ENST00000513838,
ENST00000401977,
ENST00000337581,
ENST00000506595
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000421206,
ENSP00000421139,
ENSP00000243112,
ENSP00000384828,
ENSP00000424191,
ENSP00000423629,
ENSP00000338606
RefSeq:
NP_001338189.1,
NP_055126.1,
XP_011536420.1,
NP_001338176.1,
NP_001338186.1,
NP_001230717.1,
NP_001338172.1,
NP_001338181.1,
NP_001338177.1,
NP_001338190.1,
NP_001338175.1,
XP_006719382.1,
NP_001230718.1,
NP_001338171.1,
XP_011536421.1,
NP_001338174.1,
NP_001338185.1,
XP_016874608.1,
NP_001338183.1,
NP_001338179.1,
XP_011536418.1,
NP_001338170.1,
NP_001230720.1,
NP_001338169.1,
NP_001230716.1,
NP_001338188.1,
NP_001338168.1,
XP_011536414.1,
XP_011536423.1,
NP_001338178.1,
NP_001338184.1,
NP_001338182.1,
NP_001230719.1,
NP_001338166.1,
NP_001338167.1,
NP_001338191.1,
XP_024304681.1,
NP_001338173.1,
NP_001338187.1,
NP_001338180.1
|
| Others |
UniRef100:
UniRef100_Q53HV7-2,
UniRef100_Q53HV7
UniRef90:
UniRef90_Q53HV7,
UniRef90_Q53HV7-2
UniRef50:
UniRef50_Q53HV7-2,
UniRef50_Q53HV7
UniGene:
Hs.632721,
Hs.731659
CCDS:
CCDS8874.1,
CCDS58239.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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