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7386 UQCRFS1

7386

UQCRFS1

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

研究结论

Date Results Publications
2020-10-24 14:09:00 Pulse-chase SILAC-based analyses reveal selective oversynthesis and rapid turnover of mitochondrial protein components of respiratory complexes. 31974161
2020-09-12 16:03:00 Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-kappaB/cyclin D1 pathway. 32669538
2020-04-18 10:15:00 Bi-Allelic UQCRFS1 Variants Are Associated with Mitochondrial Complex III Deficiency, Cardiomyopathy, and Alopecia Totalis. 31883641
2017-09-23 12:25:00 UQCRFS1 produces N-terminal polypeptides, which remain bound to holocomplex III. We show that, in normal conditions, these UQCRFS1 fragments are rapidly removed, but when TTC19 is absent they accumulate within complex III, causing its structural and functional impairment. 28673544
2012-04-14 10:29:00 UQCRFS1/RISP knockdown in breast tumor cell line led to decreased mitochondrial membrane potential as well as a decrease in matrigel invasion. 21901141

名称对应

Type IDs
Synonymous RIP1, RIS1, RISP, UQCR5
Gene
UniProtKB-ID: UCRI_HUMAN
UniprotKB: P47985
UniParc: UPI000013E9D6
EMBL: BC067832, L32917, AK291134, BC000649, AC007786, L32977, BC010035
Ensembl: ENSG00000169021
KO: hsa:7386
Nucleutide sequences
EMBL-CDS: AAH00649.1, AAD38242.1, AAC41754.1, BAF83823.1, AAH67832.1, AAH10035.1
Ensembl_TRS: ENST00000304863
Protein sequencees
Ensembl_PRO: ENSP00000306397
RefSeq: NP_005994.2
Others
UniRef100: UniRef100_P47985
UniRef90: UniRef90_P47985
UniRef50: UniRef50_P47985
UniGene: Hs.743307
CCDS: CCDS12415.1

全选

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