| Type | Description |
|---|---|
| Definition | trophoblast glycoprotein |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 10:31:00 | TPBG orchestrates the migratory and angiogenic activities of pericytes through the activation of the CXCL12/CXCR7/pERK axis. | 31018661 |
| 2018-11-17 11:33:00 | In extravillous trophoblasts, 5T4 may function in epithelial-to-mesenchymal transition during placentation. The role of syncytiotrophoblast 5T4 is unknown, but its abundance in shed syncytial vesicles may signify route of sensitization of the maternal immune system. | 28481180 |
| 2018-02-24 11:17:00 | Collectively, these findings demonstrate that an anti-5T4 antibody-drug conjugate reduces the fraction of cancer stem cells (CSC), and prevents local recurrence and suggest a novel therapeutic approach for patients with head and neck squamous cell carcinoma. | 27780858 |
| 2017-12-23 11:59:00 | We obtained GWS evidence (P < 2.7 x 10(-6)) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 x 10(-6)). | 28183528 |
| 2016-01-16 11:16:00 | In conclusion, the present study provided evidence that TPBG is involved in PDAC metastasis, and that TPBG and its associated signaling pathways may be a suitable target for pancreatic ductal adenocarcinoma therapy. | 25738465 |
| Type | IDs |
|---|---|
| Synonymous | 5T4, 5T4AG, M6P1, WAIF1 |
| Gene |
UniProtKB-ID:
TPBG_HUMAN
UniprotKB:
Q13641
UniParc:
UPI000004CAD5
EMBL:
Z29083,
CH471051,
AK074790,
AL121977,
AJ012159,
AK291170,
BC037161
Ensembl:
ENSG00000146242,
ENSG00000283085
KO:
hsa:7162
|
| Nucleutide sequences |
EMBL-CDS:
AAH37161.1,
BAF83859.1,
EAW48683.1,
CAA09930.1,
BAG52001.1,
CAA82324.1
Ensembl_TRS:
ENST00000543496,
ENST00000634817,
ENST00000369750,
ENST00000635036,
ENST00000634826,
ENST00000535040
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000440049,
ENSP00000358765,
ENSP00000489140,
ENSP00000441219,
ENSP00000489143,
ENSP00000489447
RefSeq:
NP_006661.1,
NP_001159864.1,
NP_001363851.1
|
| Others |
UniRef100:
UniRef100_Q13641
UniRef90:
UniRef90_Q13641
UniRef50:
UniRef50_Q13641
UniGene:
Hs.82128
CCDS:
CCDS4995.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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