| Type | Description |
|---|---|
| Definition | RAS p21 protein activator 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-06-23 10:39:00 | Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype. | 29381707 |
| 2017-06-03 12:16:00 | these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. | 27903653 |
| 2015-09-26 11:48:00 | the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. | 25294679 |
| 2010-01-21 00:00:00 | role in intracellular calcium homeostasis | 12356770 |
| 2010-01-21 00:00:00 | model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger | 19433443 |
| Type | IDs |
|---|---|
| Synonymous | GAP1IP4BP, GAPIII |
| Gene |
UniProtKB-ID:
RASA3_HUMAN
UniprotKB:
Q14644
UniParc:
UPI0001914B4B,
UPI000000DBC1
EMBL:
BC047242,
AK294913,
BX537329,
BC038456,
AL161774,
X89399,
AK289746
Ensembl:
ENSG00000185989,
ENSG00000280477
KO:
hsa:22821
|
| Nucleutide sequences |
EMBL-CDS:
CAA61580.1,
AAH38456.1,
AAH47242.1,
BAH11922.1,
BAF82435.1
Ensembl_TRS:
ENST00000630618,
ENST00000334062
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000335029,
ENSP00000486064
RefSeq:
NP_001307751.1,
NP_031394.2,
XP_016875928.1,
XP_011533143.1,
NP_001307750.1,
XP_016875927.1,
XP_011533144.1
|
| Others |
UniRef100:
UniRef100_Q14644
UniRef90:
UniRef90_Q14644
UniRef50:
UniRef50_Q14644
UniGene:
Hs.593075
CCDS:
CCDS32016.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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