| Type | Description |
|---|---|
| Definition | TLE family member 3, transcriptional corepressor |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 11:01:00 | vour findings reveal a mechanistic link between TLE3 and GR-mediated resistance to AR inhibitors in human prostate cancer | 31855178 |
| 2019-07-06 11:02:00 | RNF6-mediated ubiquitination and degradation of TLE3 activates the Wnt/beta-catenin pathway in colorectal carcinogenesis | 29374067 |
| 2018-05-12 10:02:00 | Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients. | 28859615 |
| 2017-09-30 12:03:00 | Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination. | 28689657 |
| 2017-08-19 12:04:00 | Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. | 28107193 |
| Type | IDs |
|---|---|
| Synonymous | ESG, ESG3, GRG3, HsT18976 |
| Gene |
UniProtKB-ID:
TLE3_HUMAN,
Q6PRX3_HUMAN,
B3KUA2_HUMAN,
H0YL70_HUMAN
UniprotKB:
Q04726,
Q6PRX3,
B3KUA2,
H0YL70
UniParc:
UPI000002B569,
UPI000002B56A,
UPI0000D46D7D,
UPI00022F8710,
UPI0000359527,
UPI00001C1D59,
UPI000013703A,
UPI0000E02110,
UPI00001833CC,
UPI0001D60815
EMBL:
M99438,
AK315058,
AY583459,
AK096779,
BC043247,
BC041831,
AC026583,
AB046767,
AK298482,
BC015729,
AC068327
Ensembl:
ENSG00000140332
KO:
hsa:7090
|
| Nucleutide sequences |
EMBL-CDS:
AAA61194.1,
BAG60692.1,
BAB13373.1,
AAH43247.1,
AAH41831.1,
AAS90945.1,
BAG53364.1
Ensembl_TRS:
ENST00000559048,
ENST00000558939,
ENST00000451782,
ENST00000558379,
ENST00000440567,
ENST00000557907,
ENST00000557997,
ENST00000317509,
ENST00000559929
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000452871,
ENSP00000415057,
ENSP00000453760,
ENSP00000453083,
ENSP00000453435,
ENSP00000394717,
ENSP00000319233,
ENSP00000453107,
ENSP00000453081
RefSeq:
XP_005254679.1,
XP_016878021.1,
XP_011520279.1,
XP_011520283.1,
XP_006720728.1,
XP_005254680.1,
NP_001269908.1,
XP_011520278.1,
NP_001269909.1,
NP_005069.2,
XP_011520284.1,
XP_011520281.1,
NP_001098662.1,
XP_011520282.1,
XP_005254682.1,
XP_005254690.1,
NP_001269911.1,
NP_001269910.1,
XP_011520285.1,
XP_011520280.1,
XP_005254685.1,
NP_065959.1
|
| Others |
UniRef100:
UniRef100_Q6PRX3,
UniRef100_H0YL70,
UniRef100_B3KUA2,
UniRef100_Q04726
UniRef90:
UniRef90_B3KUA2,
UniRef90_Q04726,
UniRef90_F1ML22
UniRef50:
UniRef50_Q04724,
UniRef50_Q04725-2,
UniRef50_Q04726
UniGene:
Hs.287362
CCDS:
CCDS45293.1,
CCDS61689.1,
CCDS61691.1,
CCDS45294.1,
CCDS61692.1,
CCDS58375.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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