| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase 12 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:04:00 | P38GAMMA silencing inhibits colorectal cancer (CRC) cell growth and migration. P38GAMMA silencing induces apoptosis activation in CRC cells. Ectopic P38GAMMA overexpression promotes CRC cell progression in vitro. | 31349971 |
| 2020-05-09 13:40:00 | these results indicate that ERK3 acts as a potent suppressor of melanoma cell growth and invasiveness | 30569573 |
| 2019-12-21 10:54:00 | p38 MAPK gamma (p38gamma) acts as a CDK-like kinase and thus cooperates with CDKs, regulating entry into the cell cycle; p38gamma shares high sequence homology, inhibition sensitivity and substrate specificity with CDK family members; biopsies of human hepatocellular carcinoma show high expression of p38gamma, suggesting that p38gamma could be a therapeutic target in the treatment of this disease | 30971822 |
| 2019-11-09 11:20:00 | IFN-gamma receptor stimulation requires ULK1-mediated activation of MLK3 and ERK5 | 30459284 |
| 2019-08-31 12:17:00 | p38gamma was up-regulated in breast cancer, which exerts a great influence on the cell growth, cell mobility, invasiveness, and apoptosis of MDA-MB-231 cells and also affected the metabolism | 30447427 |
| Type | IDs |
|---|---|
| Synonymous | ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3 |
| Gene |
UniProtKB-ID:
MK12_HUMAN,
Q6N076_HUMAN
UniprotKB:
P53778,
Q6N076
UniParc:
UPI000012F180,
UPI0001AE6306,
UPI00001BDB6F
EMBL:
AL022328,
X79483,
BC015741,
U66243,
CR456515,
Y10487,
BX640648
Ensembl:
ENSG00000188130
KO:
hsa:6300
|
| Nucleutide sequences |
EMBL-CDS:
CAA55984.1,
CAA71511.1,
CAG30401.1,
AAB40118.1,
AAH15741.1,
CAE45794.1
Ensembl_TRS:
ENST00000622558,
ENST00000215659
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000215659,
ENSP00000479972
RefSeq:
NP_001290181.1,
NP_002960.2
|
| Others |
UniRef100:
UniRef100_P53778,
UniRef100_Q6N076
UniRef90:
UniRef90_A0A2R9A7E0,
UniRef90_P53778
UniRef50:
UniRef50_P53778,
UniRef50_G1NX89
UniGene:
Hs.432642
CCDS:
CCDS77688.1,
CCDS14089.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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