| Type | Description |
|---|---|
| Definition | SIN3 transcription regulator family member A |
| Date | Results | Publications |
|---|---|---|
| 2020-01-25 14:32:00 | We showed that ARID1A directly caused suppression of TERT and was reliant on DNA binding and co-occupancy of the TERT promoter by the SIN3 transcription regulator family member A (SIN3A) repressor complex allowing neuroblastoma (NB) differentiation to proceed. | 31365169 |
| 2019-12-14 12:15:00 | Here the authors report the identification of a highly conserved Sin3-interaction domain in the 5-methylcytosine dioxygenase, Tet1 (Tet1-SID), which interacts directly with the PAH1 domain of Sin3A. | 30279502 |
| 2019-10-26 11:31:00 | The SIN3A mutation obviously enhanced MCF7 cell proliferation. In tissue sections from the breast cancer patient with the SIN3A c.2830 C>T mutation, cytoplasmic SIN3A localization was detected within the tumor regions where nuclear enlargement was observed. | 30375428 |
| 2019-09-14 11:00:00 | LSD1 coordinates with the SIN3A/HDAC complex in inhibiting a series of genes such as CASP7, TGFB2, CDKN1A(p21), HIF1A, TERT, and MDM2, some of which are oncogenic. | 29741645 |
| 2019-07-13 11:34:00 | Results reveal a prominent role for transcriptional regulator SIN3A (SIN3A) in the transcriptional response to hypoxia, and suggesting a model where modulation of the associated histone deacetylase 1/2 activity, rather than its recruitment, determines the transcriptional output. | 29059365 |
| Type | IDs |
|---|---|
| Synonymous | WITKOS |
| Gene |
UniProtKB-ID:
SIN3A_HUMAN
UniprotKB:
Q96ST3
UniParc:
UPI000013EAD4
EMBL:
BC018973,
AY044430,
AL117513,
AK027559,
AF418569,
BC137098,
AK096477,
AK074903,
BC137099
Ensembl:
ENSG00000169375
KO:
hsa:25942
|
| Nucleutide sequences |
EMBL-CDS:
AAH18973.1,
AAK95854.1,
AAI37099.1,
CAB55972.1,
AAI37100.1,
BAB55197.1,
BAC04801.1,
BAC11280.1,
AAP97288.1
Ensembl_TRS:
ENST00000394949,
ENST00000394947,
ENST00000360439
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000378403,
ENSP00000378402,
ENSP00000353622
RefSeq:
NP_056292.1,
XP_006720528.1,
XP_006720530.1,
XP_006720529.1,
XP_024305664.1,
NP_001138830.1,
NP_001138829.1
|
| Others |
UniRef100:
UniRef100_Q96ST3
UniRef90:
UniRef90_Q96ST3
UniRef50:
UniRef50_Q96ST3
UniGene:
Hs.513039
CCDS:
CCDS10279.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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