| Type | Description |
|---|---|
| Definition | neurolysin |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 10:10:00 | The crystal structure of human neurolysin(E475Q) in complex with the products of neurotensin cleavage at 2.7A revealed a closed conformation with an internal cavity that restricts substrate length and highlighted the mechanism of enzyme opening/closing that is necessary for substrate binding and catalytic activity. | 29183787 |
| 2010-12-05 22:08:00 | Observational study of gene-disease association. (HuGE Navigator) | 20877624 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| 2010-01-21 00:00:00 | Mutations at only two residues (Arg-470 and Arg-498) are required to swap specificity with thimet oligopeptidase, a result that is confirmed by testing the two-mutant constructs. | 17251185 |
| Type | IDs |
|---|---|
| Synonymous | AGTBP, EP24.16, MEP, MOP |
| Gene |
UniProtKB-ID:
NEUL_HUMAN
UniprotKB:
Q9BYT8
UniParc:
UPI000003989D
EMBL:
AJ300837,
AB033052
Ensembl:
ENSG00000123213
KO:
hsa:57486
|
| Nucleutide sequences |
EMBL-CDS:
BAA86540.2,
CAC27329.1
Ensembl_TRS:
ENST00000380985
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370372
RefSeq:
XP_006714724.1,
NP_065777.1,
XP_005248616.1,
XP_016865162.1
|
| Others |
UniRef100:
UniRef100_Q9BYT8
UniRef90:
UniRef90_Q02038
UniRef50:
UniRef50_Q02038
UniGene:
Hs.247460
CCDS:
CCDS3989.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31586073 |
The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Nat Commun Luisa Capalbo , Zuni I Bassi , Marco Geymonat , Sofia Todesca , Liviu Copoiu , Anton J Enright , Giuliano Callaini , Maria Giovanna Riparbelli , Lu Yu , Jyoti S Choudhary , Enrico Ferrero , Sally Wheatley , Max E Douglas , Masanori Mishima , Pier Paolo D'Avino |
2019-10-04 | - |
| 30021884 |
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck |
2018-10-01 | - |
| 29183787 |
Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin. J. Mol. Biol. Pedro F Teixeira , Geoffrey Masuyer , Catarina M Pinho , Rui M M Branca , Beata Kmiec , Cecilia Wallin , Sebastian K T S Wärmländer , Ronnie P-A Berntsson , Maria Ankarcrona , Astrid Gräslund , Janne Lehtiö , Pål Stenmark , Elzbieta Glaser |
2018-02-02 | - |
| 29128334 |
Cell Syst Ramy H Malty , Hiroyuki Aoki , Ashwani Kumar , Sadhna Phanse , Shahreen Amin , Qingzhou Zhang , Zoran Minic , Florian Goebels , Gabriel Musso , Zhuoran Wu , Hosam Abou-Tok , Michael Meyer , Viktor Deineko , Sandy Kassir , Vishaldeep Sidhu , Matthew Jessulat , Nichollas E Scott , Xuejian Xiong , James Vlasblom , Bhanu Prasad , Leonard J Foster , Tiziana Alberio , Barbara Garavaglia , Haiyuan Yu , Gary D Bader , Ken Nakamura , John Parkinson , Mohan Babu |
2017-12-27 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 28380382 |
Cell Metab. Nunziata Maio , Ki Soon Kim , Anamika Singh , Tracey A Rouault |
2017-04-04 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
| 26344197 |
Panorama of ancient metazoan macromolecular complexes. Nature Cuihong Wan , Blake Borgeson , Sadhna Phanse , Fan Tu , Kevin Drew , Greg Clark , Xuejian Xiong , Olga Kagan , Julian Kwan , Alexandr Bezginov , Kyle Chessman , Swati Pal , Graham Cromar , Ophelia Papoulas , Zuyao Ni , Daniel R Boutz , Snejana Stoilova , Pierre C Havugimana , Xinghua Guo , Ramy H Malty , Mihail Sarov , Jack Greenblatt , Mohan Babu , W Brent Derry , Elisabeth R Tillier , John B Wallingford , John Parkinson , Edward M Marcotte , Andrew Emili |
2015-09-17 |
AKT3,
MED6,
ABI1,
GNPDA1,
SRA1,
TDRD15,
HMGN1P30,
PDCD6IP,
PDCD6,
MED16,
ADA,
CHAF1A,
TOM1,
RANBP9,
SMC4,
ARPC4-TTLL3,
RBM14-RBM4,
RNF103-CHMP3,
CHURC1-FNTB,
AP1M2,
ISY1-RAB43,
UBA2,
SAE1,
FARSB,
DNM1L,
ABCF2,
COX17,
SCAMP2,
SCAMP3,
DPP3,
SNUPN,
HUWE1,
TSSC4,
ATP9A,
PQBP1,
COL4A3BP,
PTGES3L-AARSD1,
ARPC5,
ARPC4,
ARPC3,
ARPC1B,
ACTR3,
ACTR2,
NUBP2,
PPIF,
LOC101060521,
ARPC2,
RAD50,
ACTR1B,
ACTR1A,
ADAM8,
LRPPRC,
PDIA6,
TRAP1,
BCAP31,
NAMPT,
RBM12,
G3BP1,
ABI2,
CEBPZ,
TRIM28,
AASS,
ATP6AP2,
WASF2,
SLC25A13,
CDK2,
RBM7,
ALYREF,
TXNDC9,
LOC101929876,
PSME3,
MPHOSPH10,
MPHOSPH6,
CDK5,
NUTF2,
EIF1,
DDX39A,
PSMD14,
CDK7,
PLIN3,
HNRNPR,
MRPS31,
CDK8,
RABEPK,
RIDA,
SRRM1,
CDK9,
STAM2,
SF3B4,
ZMPSTE24,
AKAP8,
STUB1,
STAG1,
UBE4B,
PRSS16,
SIGMAR1,
BET1,
CWC27,
SAP18
|
| 26186194 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin Wühr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi |
2015-07-16 | - |
| 25367360 |
Hum. Genet. Qing Li , Robert Wojciechowski , Claire L Simpson , Pirro G Hysi , Virginie J M Verhoeven , Mohammad Kamran Ikram , René Höhn , Veronique Vitart , Alex W Hewitt , Konrad Oexle , Kari-Matti Mäkelä , Stuart MacGregor , Mario Pirastu , Qiao Fan , Ching-Yu Cheng , Beaté St Pourcain , George McMahon , John P Kemp , Kate Northstone , Jugnoo S Rahi , Phillippa M Cumberland , Nicholas G Martin , Paul G Sanfilippo , Yi Lu , Ya Xing Wang , Caroline Hayward , Ozren Polašek , Harry Campbell , Goran Bencic , Alan F Wright , Juho Wedenoja , Tanja Zeller , Arne Schillert , Alireza Mirshahi , Karl Lackner , Shea Ping Yip , Maurice K H Yap , Janina S Ried , Christian Gieger , Federico Murgia , James F Wilson , Brian Fleck , Seyhan Yazar , Johannes R Vingerling , Albert Hofman , André Uitterlinden , Fernando Rivadeneira , Najaf Amin , Lennart Karssen , Ben A Oostra , Xin Zhou , Yik-Ying Teo , E Shyong Tai , Eranga Vithana , Veluchamy Barathi , Yingfeng Zheng , Rosalynn Grace Siantar , Kumari Neelam , Youchan Shin , Janice Lam , Ekaterina Yonova-Doing , Cristina Venturini , S Mohsen Hosseini , Hoi-Suen Wong , Terho Lehtimäki , Mika Kähönen , Olli Raitakari , Nicholas J Timpson , David M Evans , Chiea-Chuen Khor , Tin Aung , Terri L Young , Paul Mitchell , Barbara Klein , Cornelia M van Duijn , Thomas Meitinger , Jost B Jonas , Paul N Baird , David A Mackey , Tien Yin Wong , Seang-Mei Saw , Olavi Pärssinen , Dwight Stambolian , Christopher J Hammond , Caroline C W Klaver , Cathy Williams , Andrew D Paterson , Joan E Bailey-Wilson , Jeremy A Guggenheim , CREAM Consortium |
2015-02-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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{{author.size}} |
目前还没有研究热点人员