| Type | Description |
|---|---|
| Definition | tyrosyl-DNA phosphodiesterase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:36:00 | Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases. | 32653827 |
| 2020-05-09 13:14:00 | Data suggest that tyrosyl-DNA phosphodiesterase 1 (TDP1) in mitochondria creates a pathological state that allows neurons to turn on mitophagy to rescue fit mitochondria as a mechanism of survival. | 31723605 |
| 2019-12-14 12:37:00 | These results demonstrate that fragment-based methods can be a highly feasible approach toward the discovery of small-molecule chemical scaffolds to target TDP1, and for the first time, we provide co-crystal structures of small molecule inhibitors bound to TDP1, which could serve for the rational development of medicinal TDP1 inhibitors. | 31199869 |
| 2019-12-14 12:04:00 | This article reviews TDP1 and TDP2 in the context of mitochondrial DNA repair. [review] | 31226795 |
| 2019-07-27 12:07:00 | Data suggest that tyrosyl-DNA Phosphodiesterases 1 (TDP1) and 2 (TDP2) are promising therapeutic targets and their inhibitors are expected to significantly synergize the effects of current anti-tumor therapies [Review]. | 29216365 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TYDP1_HUMAN,
B3KN41_HUMAN,
A0A024R6L5_HUMAN,
G3V2F4_HUMAN
UniprotKB:
Q9NUW8,
B3KN41,
A0A024R6L5,
G3V2F4
UniParc:
UPI0000D4E4BB,
UPI000015F545,
UPI000000CC5B,
UPI00000737ED
EMBL:
AF182002,
BC015474,
AL137128,
AK001952,
AF182003,
CH471061,
BX161451,
DQ367843,
AK023514
Ensembl:
ENSG00000042088
KO:
hsa:55775
|
| Nucleutide sequences |
EMBL-CDS:
AAH15474.1,
ABC79301.1,
AAF65623.1,
BAA91997.1,
CAD61915.1,
AAF65624.1,
BAG51203.1,
EAW81414.1,
EAW81415.1,
EAW81416.1
Gene_ORFName:
hCG_21753
Ensembl_TRS:
ENST00000335725,
ENST00000393454,
ENST00000555880
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377099,
ENSP00000337353,
ENSP00000450628
RefSeq:
NP_001317134.1,
XP_024305421.1,
XP_024305417.1,
XP_016876929.1,
XP_005267905.1,
XP_024305423.1,
NP_001008744.1,
XP_024305419.1,
XP_024305422.1,
XP_024305418.1,
XP_024305426.1,
XP_016876928.1,
XP_024305425.1,
XP_011535246.1,
XP_024305427.1,
NP_060789.2,
XP_024305424.1,
XP_024305420.1,
XP_011535244.1,
XP_006720260.1
|
| Others |
UniRef100:
UniRef100_G3V2F4,
UniRef100_Q9NUW8
UniRef90:
UniRef90_Q9NUW8,
UniRef90_G3V2F4
UniRef50:
UniRef50_Q9NUW8
UniGene:
Hs.209945
CCDS:
CCDS9888.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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