| Type | Description |
|---|---|
| Definition | WD repeat domain 74 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:24:00 | WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5-MDM2-p53 pathway. | 32005977 |
| 2020-08-29 12:45:00 | WDR74 induces nuclear beta-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis. | 31838084 |
| 2019-09-07 12:23:00 | Through direct interactions with Smad proteins, WDR74 enhances TGF-beta-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. | 30594465 |
| 2018-01-20 10:27:00 | knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed. | 29107693 |
| 2016-02-20 11:19:00 | results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis | 26456651 |
| Type | IDs |
|---|---|
| Synonymous | Nsa1 |
| Gene |
UniProtKB-ID:
WDR74_HUMAN
UniprotKB:
Q6RFH5
UniParc:
UPI000013DB9A,
UPI00000372EB
EMBL:
AK001301,
BC006351,
AY500828,
AK025383,
AK292330
Ensembl:
ENSG00000133316
KO:
hsa:54663
|
| Nucleutide sequences |
EMBL-CDS:
BAF85019.1,
BAA91610.1,
AAS48499.1,
BAB15122.1,
AAH06351.1
Ensembl_TRS:
ENST00000525239,
ENST00000278856,
ENST00000311713,
ENST00000529106
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000435726,
ENSP00000308931,
ENSP00000278856,
ENSP00000432119
RefSeq:
NP_001356379.1,
NP_001356376.1,
NP_001356377.1,
NP_001356378.1,
NP_001356380.1,
NP_001294906.1,
NP_060563.2,
NP_001356382.1
|
| Others |
UniRef100:
UniRef100_Q6RFH5
UniRef90:
UniRef90_Q6RFH5
UniRef50:
UniRef50_Q6RFH5
UniGene:
Hs.654620
CCDS:
CCDS44630.1,
CCDS76421.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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