| Type | Description |
|---|---|
| Definition | fission, mitochondrial 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 10:54:00 | In human EPCs, down-regulation of Fis1 is involved in mitochondrial dysfunction and contributes to the impaired activity of EPCs during the senescence process. Enhanced expression of Fis1 in senescent EPCs restores the youthful phenotype. | 31482366 |
| 2020-02-15 13:47:00 | FIS1 and PDCD7 expression are considered independent risk factors and should be integrated into the current acute myeloid leukemia stratification system | 30555023 |
| 2019-10-05 11:02:00 | data suggest a model in which leukemia stem cells co-opt AMPK/FIS1-mediated mitophagy as a means to maintain stem cell properties that may be otherwise compromised by the stresses induced by oncogenic transformation | 29910151 |
| 2019-06-08 11:15:00 | Study demonstrated that the STX17 initiates mitophagy upon depletion of outer mitochondrial membrane protein Fis1. Fis1 loss results in aberrant STX17 accumulation on mitochondria, which exposes the N terminus and promotes self-oligomerization to trigger mitophagy. Findings uncover a PINK1/Parkin-independent mitophagic mechanism in which outer mitochondrial membrane protein Fis1 regulates mitochondrial quality control. | 31053718 |
| 2019-03-02 10:52:00 | Glomerular overproduction of Drp1, phospho-Drp1 (Ser 616) and Fis1 occurred mainly in children with membranous nephropathy. | 30566949 |
| Type | IDs |
|---|---|
| Synonymous | CGI-135, TTC11 |
| Gene |
UniProtKB-ID:
FIS1_HUMAN
UniprotKB:
Q9Y3D6
UniParc:
UPI000007214F
EMBL:
BC003540,
AC006329,
BC009428,
AF151893
Ensembl:
ENSG00000214253
KO:
hsa:51024
|
| Nucleutide sequences |
EMBL-CDS:
AAD34130.1,
AAP22366.1,
AAH09428.1,
AAH03540.1
Gene_ORFName:
CGI-135
Ensembl_TRS:
ENST00000223136
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000223136
RefSeq:
NP_057152.2
|
| Others |
UniRef100:
UniRef100_Q9Y3D6
UniRef90:
UniRef90_Q9Y3D6
UniRef50:
UniRef50_Q9Y3D6
UniGene:
Hs.423968
CCDS:
CCDS43626.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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