| Type | Description |
|---|---|
| Definition | syntaxin binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:48:00 | Different Clinical Presentation of 3 Children With Familial Hemophagocytic Lymphohistiocytosis With 2 Novel Mutations. | 31651726 |
| 2019-05-11 11:49:00 | In the current study, we have made the unexpected observation that congenital deficiency of the STXBP2 protein may also affect the expression of STXBP1. Further analysis identified an unsuspected functional role for STXBP1 in secretory granule-mediated NK and T-cell cytotoxicity. | 29599780 |
| 2019-05-04 10:19:00 | Loss of Munc18-2/Stxbp2 recapitulated the pathologic features observed in patients with MUNC18-2 deficiency. | 30364784 |
| 2018-08-11 10:11:00 | Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. | 29044293 |
| 2018-03-10 11:38:00 | Among these nine polymorphisms, rs188212047 [G/T (L212F)] of STXBP2 was significantly (dominant model; P = 4.84 x 10-8; odds ratio, 2.94) associated with myocardial infarction. STXBP2 may thus be a novel susceptibility locus for myocardial infarction in Japanese. | 28380445 |
| Type | IDs |
|---|---|
| Synonymous | FHL5, Hunc18b, MUNC18-2, UNC18-2, UNC18B, pp10122 |
| Gene |
UniProtKB-ID:
STXB2_HUMAN,
Q53GF4_HUMAN
UniprotKB:
Q15833,
Q53GF4
UniParc:
UPI0001AE6405,
UPI0000070E86,
UPI000013C7B8,
UPI000050A82C
EMBL:
BC002869,
AK222977,
AK303701,
CH471139,
U63533,
AC008763,
BT006915,
AK222967
Ensembl:
ENSG00000076944
KO:
hsa:6813
|
| Nucleutide sequences |
EMBL-CDS:
AAC50762.1,
EAW69018.1,
BAG64687.1,
AAH02869.1,
AAP35561.1,
BAD96697.1,
BAD96687.1
Ensembl_TRS:
ENST00000414284,
ENST00000441779,
ENST00000221283
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000413606,
ENSP00000221283,
ENSP00000409471
RefSeq:
XP_011526512.1,
NP_001120868.1,
NP_001258963.1,
NP_008880.2,
XP_011526514.1
|
| Others |
UniRef100:
UniRef100_Q53GF4,
UniRef100_Q15833
UniRef90:
UniRef90_Q15833
UniRef50:
UniRef50_Q15833
UniGene:
Hs.515104
CCDS:
CCDS62522.1,
CCDS12181.1,
CCDS45948.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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