| Type | Description |
|---|---|
| Definition | myristoylated alanine rich protein kinase C substrate |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:40:00 | MARCKS inhibition cooperates with autophagy antagonists to potentiate the effect of standard therapy against drug-resistant multiple myeloma. | 32220540 |
| 2020-06-13 11:52:00 | MARCKS was overexpressed in epithelial tumor cells in 66% of the MBC samples versus 26% of normal samples (p= 1.40 x 10-7). Such positive MARCKS expression in epithelial tumor cells was associated with positive HER2 status (p= 4.0 x 10-3). | 31771045 |
| 2020-04-04 12:31:00 | Cells devoid of MARCKS function showed incomplete ABCB1 internalization, leading to higher ABCB1 activity enhancing chemoresistance. | 32056006 |
| 2020-02-01 10:40:00 | Morphine at 10(-6) mol/l could benefit miR-543 expression to inhibit MARCKS expression. | 31373006 |
| 2019-08-31 12:53:00 | Study, using a tetracyclineinducible system in PTENnull U87 cells, demonstrated that MARCKS overexpression suppresses growth and enhances radiation sensitivity in vivo. The overexpression of the nonphosphorylatable effector domain (ED) mutant exerted growthsuppressive and radiationsensitizing effects, while the pseudophosphorylated ED mutant exhibited an enhanced colony formation and clonogenic survival ability. | 30942445 |
| Type | IDs |
|---|---|
| Synonymous | 80K-L, MACS, PKCSL, PRKCSL |
| Gene |
UniProtKB-ID:
MARCS_HUMAN,
Q6NVI1_HUMAN
UniprotKB:
P29966,
Q6NVI1
UniParc:
UPI00001BD9EF,
UPI000013DDF0
EMBL:
CH471051,
AL132660,
D10522,
M68956,
BC068059,
BC013004,
DQ341274,
BC089040,
M68955
Ensembl:
ENSG00000277443
KO:
hsa:4082
|
| Nucleutide sequences |
EMBL-CDS:
AAA59555.1,
AAA59554.1,
ABC67467.1,
EAW48259.1,
EAW48258.1,
BAA01392.1,
AAH89040.1,
CAI19942.1,
AAH13004.1,
AAH68059.1
Ensembl_TRS:
ENST00000612661
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000478061
RefSeq:
NP_002347.5
|
| Others |
UniRef100:
UniRef100_P29966,
UniRef100_Q6NVI1
UniRef90:
UniRef90_P29966,
UniRef90_Q6NVI1
UniRef50:
UniRef50_P29966,
UniRef50_Q6NVI1
UniGene:
Hs.519909,
Hs.712658
CCDS:
CCDS5101.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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