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4839 NOP2

4839

NOP2

NOP2 nucleolar protein

protein-coding

Homo sapiens

基因描述

Type Description
Definition NOP2 nucleolar protein

研究结论

Date Results Publications
2021-03-13 13:22:00 Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer. 32554858
2020-06-27 12:29:00 Mechanistically, NOP2 associates with HIV-1 5' LTR, interacts with HIV-1 TAR RNA by competing with HIV-1 Tat protein, as well as contributes to TAR m5C methylation. RNA MTase catalytic domain (MTD) of NOP2 mediates its competition with Tat and binding with TAR. Overall, these findings verified that NOP2 suppresses HIV-1 transcription and promotes viral latency. 32176734
2017-01-14 10:19:00 NOL1 represents a new route by which telomerase activates transcription of cyclin D1 gene, thus maintaining cell proliferation capacity 26906424
2016-05-07 10:43:00 p120 has an rRNA:5-Methylcytosine-Methyltransferase activity. 26196125
2015-11-28 11:33:00 Findings suggest a newly discovered role of Nop2 in both mature neurons and in cells possibly involved in the regeneration of nervous tissue 25481415

名称对应

Type IDs
Synonymous NOL1, NOP120, NSUN1, p120
Gene
UniProtKB-ID: NOP2_HUMAN
UniprotKB: P46087
UniParc: UPI00005C3039, UPI0000D4C2A1, UPI00003718DD, UPI00000373D6
EMBL: AK056208, BC106072, X55504, BC065257, AC006064, M32110, BC082985, BC128183, M33132, BC000656, BC128184
Ensembl: ENSG00000111641
KO: hsa:4839
Nucleutide sequences
EMBL-CDS: AAA36398.1, CAA39119.1, AAH65257.1, AAI28185.1, BAG51648.1, AAH00656.1, AAI28184.1, AAH82985.1, AAI06073.1
Ensembl_TRS: ENST00000541778, ENST00000617555, ENST00000382421, ENST00000545200, ENST00000537442, ENST00000399466, ENST00000620535, ENST00000322166
Protein sequencees
Ensembl_PRO: ENSP00000444437, ENSP00000371858, ENSP00000479320, ENSP00000313272, ENSP00000443150, ENSP00000382392, ENSP00000439422, ENSP00000484384
RefSeq: XP_005253748.1, NP_001245239.1, NP_001028886.1, NP_001245237.1, NP_001245238.1, NP_006161.2
Others
UniRef100: UniRef100_P46087
UniRef90: UniRef90_P46087
UniRef50: UniRef50_P46087
UniGene: Hs.534334
CCDS: CCDS58202.1, CCDS58203.1, CCDS44811.1, CCDS58204.1

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