| Type | Description |
|---|---|
| Definition | thioredoxin domain containing 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:28:00 | Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization. | 32848143 |
| 2020-06-06 13:46:00 | serum levels were elevated in both early-onset and late-onset pre-eclampsia | 30522366 |
| 2020-01-18 10:57:00 | HERG1 contributes to poor prognosis in patients with esophageal squamous cell carcinoma (ESCC) by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through the PI3K/AKT signaling pathway. Our findings provided novel insights into the pathology of ESCC and role of HERG1 in tumor progression, suggesting that targeting HERG1 has potential diagnostic and therapeutic value for ESCC treatment. | 31331361 |
| 2019-10-26 10:23:00 | These results strongly suggest that high levels of TXNDC5 in Rheumatoid Arthritis synovial tissues suppress CXCL10 and TNFSF10 expression. | 29247155 |
| 2019-10-05 12:50:00 | Taken together, by linking HSC70 and NF-kappaB signaling, TXNDC5 plays a pro-inflammatory role in rheumatoid arthritis synovial fibroblasts, highlighting a potential approach to treat rheumatoid arthritis by blocking the TXNDC5/HSC70 interaction. | 28603283 |
| Type | IDs |
|---|---|
| Synonymous | ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364 |
| Gene |
UniProtKB-ID:
TXND5_HUMAN,
A0A024QZV0_HUMAN
UniprotKB:
Q8NBS9,
A0A024QZV0
UniParc:
UPI0000048EC3,
UPI0000062265
EMBL:
AL834423,
BC001199,
AL133541,
GQ891501,
AK075291,
AJ440721,
AL096800,
AK315598,
AY358646,
CH471087,
AL023694
Ensembl:
ENSG00000239264
KO:
hsa:81567
|
| Nucleutide sequences |
EMBL-CDS:
BAC11526.1,
AAQ89009.1,
CAD29430.1,
CAD39084.1,
AAH01199.1,
EAW55221.1,
BAG37969.1,
ADO22363.1,
EAW55222.1
Gene_ORFName:
UNQ364/PRO700,
hCG_1811539
Ensembl_TRS:
ENST00000379757,
ENST00000473453
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000420784,
ENSP00000369081
RefSeq:
NP_001139021.1,
NP_110437.2
|
| Others |
UniRef100:
UniRef100_Q8NBS9
UniRef90:
UniRef90_Q8NBS9
UniRef50:
UniRef50_Q8NBS9
UniGene:
Hs.150837
CCDS:
CCDS47369.1,
CCDS4505.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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