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58472 SQOR

58472

SQOR

sulfide quinone oxidoreductase

protein-coding

Homo sapiens

基因描述

Type Description
Definition sulfide quinone oxidoreductase

研究结论

Date Results Publications
2020-06-13 12:28:00 human SQOR contains unique features: an electropositive surface depression implicated as a binding site for sulfane sulfur acceptors and postulated to funnel negatively charged substrates to a hydrophilic H2S-oxidizing active site, which is connected to a hydrophobic internal tunnel that binds coenzyme Q 30905673
2018-12-22 10:37:00 The evidence supported the significant role of SQRDL in the etiology of postmenopausal osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women. 29855663
2018-09-19 08:12:00 Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase 26318450
2017-09-30 10:43:00 Therefore, this study reveals the reduction in SQR activity as one of the pathomechanisms associated with Coenzyme Q deficiency syndrome. 27856619
2017-08-05 13:06:00 Data, including data from studies using recombinant SQR immobilized by embedding in nanodiscs, suggest that immobilized SQR exhibits enhanced catalytic performance; pre-steady-state kinetic characterization of immobilized SQR catalytic cycle indicates that glutathione serves as physiologically relevant sulfur acceptor during hydrogen sulfide oxidation. 28512131

名称对应

Type IDs
Synonymous CGI-44, PRO1975, SQR, SQRDL
Gene
UniProtKB-ID: SQOR_HUMAN, A0A024R5X2_HUMAN
UniprotKB: Q9Y6N5, A0A024R5X2
UniParc: UPI0000135EA5
EMBL: AF151802, AF042284, CH471082, BC016836
Ensembl: ENSG00000137767
KO: hsa:58472
Nucleutide sequences
EMBL-CDS: AAD41160.1, AAD34039.1, AAH16836.1, EAW77328.1, EAW77321.1, EAW77319.1, EAW77326.1, EAW77324.1
Gene_ORFName: CGI-44, hCG_2001986
Ensembl_TRS: ENST00000260324, ENST00000568606
Protein sequencees
Ensembl_PRO: ENSP00000260324, ENSP00000456019
RefSeq: NP_067022.1, NP_001258142.1
Others
UniRef100: UniRef100_Q9Y6N5
UniRef90: UniRef90_Q9Y6N5
UniRef50: UniRef50_Q9Y6N5
UniGene: Hs.511251, Hs.743355
CCDS: CCDS10127.1

全选

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