| Type | Description |
|---|---|
| Definition | RAS like proto-oncogene A |
| Date | Results | Publications |
|---|---|---|
| 2020-01-04 11:38:00 | RalA and RalB both relocalize to mitochondria following depolarization in a process dependent on clathrin-mediated endocytosis. Furthermore, both genetic and pharmacologic inhibition of RalA and RalB leads to an increase in the activity of the atypical IkappaB kinase TBK1 both basally and in response to mitochondrial depolarization. | 30995277 |
| 2019-02-09 11:49:00 | These results show the power of data sharing for the interpretation and analysis of rare variation, expand the spectrum of molecular causes of developmental disability to include RALA, and provide additional insight into the pathogenesis of human disease caused by mutations in small GTPases. | 30500825 |
| 2018-10-06 12:02:00 | In fact the overexpression of RalGPS2 or of its PH-domain increased markedly the number and the length of nanotubes, while the knock-down of RalGPS2 caused a strong reduction of these structures. Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5, Exo84, RalBP1) we demonstrated that the interaction of RalA with Sec5 is required for TNTs formation | 29208460 |
| 2018-09-01 10:25:00 | Study explored the function of RalA in regulating the localization of AQP3 in androgenindependent prostate cancer and demonstrated that depletion of RalA led to the redistribution of AQP3 into the plasma membrane. | 29532894 |
| 2018-03-10 10:43:00 | Data show that ras related GTP binding protein A (Ral A) is necessary for 1-O-Hexadecyl-2-O-methyl-rac-glycerol (HMG)-mediated M phase arrest and induction of apoptosis in Nf1-deficient cells. | 27741517 |
| Type | IDs |
|---|---|
| Synonymous | RAL |
| Gene |
UniProtKB-ID:
RALA_HUMAN
UniprotKB:
P11233
UniParc:
UPI0000001C8F
EMBL:
X15014,
BC039858,
CH471073,
M29893,
AC004837,
AF493910,
CH236951
Ensembl:
ENSG00000006451
KO:
hsa:5898
|
| Nucleutide sequences |
EMBL-CDS:
AAA36542.1,
EAL23994.1,
EAW94123.1,
AAH39858.1,
AAM12624.1,
CAA33118.1
Ensembl_TRS:
ENST00000005257
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000005257
RefSeq:
XP_011513768.1,
XP_006715825.1,
XP_011513769.1,
NP_005393.2
|
| Others |
UniRef100:
UniRef100_P11233
UniRef90:
UniRef90_P11233
UniRef50:
UniRef50_P11233
UniGene:
Hs.6906
CCDS:
CCDS5460.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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