| Type | Description |
|---|---|
| Definition | F-box and leucine rich repeat protein 18 |
| Date | Results | Publications |
|---|---|---|
| 2018-03-03 11:12:00 | Study showed that LRRK2 phosphorylation is required for LRRK2 to bind to Fbxl18, and that this interaction is important for regulating the amount of LRRK2 via ubiquitination of LRRK2 by the SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation of LRRK2. We also show that LRRK2 can induce caspase 8 mediated cell death and that the degradation of LRRK2 mediated by Fbxl18 can prevent LRRK2-mediated toxicity. | 27890708 |
| 2017-05-27 11:53:00 | FBXL18 plays an oncogenic role through promoting lysine 63-linked ubiquitination of Akt in glioma. | 27926990 |
| 2015-09-12 10:21:00 | Fbxl18 regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein Fbxl7 that may impact cellular processes involved in cell cycle progression. | 25654763 |
| Type | IDs |
|---|---|
| Synonymous | Fbl18 |
| Gene |
UniProtKB-ID:
B4DH63_HUMAN,
A0A024R857_HUMAN,
Q96D16_HUMAN
UniprotKB:
B4DH63,
A0A024R857,
Q96D16
UniParc:
UPI000020EA59,
UPI00017A703B,
UPI000006DC24
EMBL:
CH471144,
AC092171,
AK294949,
AC006483,
BC013435
Ensembl:
ENSG00000155034
KO:
hsa:80028
|
| Nucleutide sequences |
EMBL-CDS:
BAG58024.1,
EAW87339.1,
EAW87338.1,
AAH13435.1
Gene_ORFName:
hCG_1993852
Ensembl_TRS:
ENST00000620087
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000481397
RefSeq:
NP_001354710.1,
NP_001354709.1,
NP_001350370.1,
NP_001350371.1,
NP_001308142.1,
NP_079239.3
|
| Others |
UniRef100:
UniRef100_B4DH63,
UniRef100_Q96D16,
UniRef100_A0A024R857
UniRef90:
UniRef90_Q96ME1,
UniRef90_Q96D16
UniRef50:
UniRef50_Q96D16,
UniRef50_Q96ME1
UniGene:
Hs.623974,
Hs.706587
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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