| Type | Description |
|---|---|
| Definition | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 12:45:00 | A novel gene fusion between the LAMTOR1 and AKT1 was identified in a histopathologically indeterminate epithelioid neoplasm of a patient. This fusion resulted in oncogenic activatin of AKT1. | 30877085 |
| 2019-09-21 10:59:00 | The Lamtor1 dynamically controls cellular function via mTORC1 activation and lipid signaling. | 30806216 |
| 2019-02-16 11:15:00 | We found that under nutrient-rich conditions TMEM127 expression reduces mTORC1 recruitment to Rags. In addition, TMEM127 interacts with LAMTOR in an amino acid-dependent manner and decreases the LAMTOR1-vATPase association, while TMEM127-vATPase binding requires intact lysosomal acidification but is amino acid independent | 29547888 |
| 2018-01-13 10:14:00 | In vitro reconstitution and experiments with site-directed mutagenesis defined the physiological importance of LAMTOR1 in assembling the remaining components to ensure fidelity of mTORC1 signaling. | 28935770 |
| 2017-12-09 12:07:00 | LAMTOR1 is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. | 28993467 |
| Type | IDs |
|---|---|
| Synonymous | C11orf59, PDRO, Ragulator1, p18, p27RF-Rho |
| Gene |
UniProtKB-ID:
LTOR1_HUMAN
UniprotKB:
Q6IAA8
UniParc:
UPI0000049CB7
EMBL:
CR457247,
BC001706,
AK000632,
AF289583
Ensembl:
ENSG00000149357
KO:
hsa:55004
|
| Nucleutide sequences |
EMBL-CDS:
AAH01706.1,
CAG33528.1,
BAA91297.1,
AAL55767.1
Gene_ORFName:
PP7157
Ensembl_TRS:
ENST00000278671
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000278671
RefSeq:
NP_060377.1
|
| Others |
UniRef100:
UniRef100_Q6IAA8
UniRef90:
UniRef90_Q6IAA8
UniRef50:
UniRef50_Q6IAA8
UniGene:
Hs.731528
CCDS:
CCDS8209.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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