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3856 KRT8

3856

KRT8

keratin 8

protein-coding

Homo sapiens

基因描述

Type Description
Definition keratin 8

研究结论

Date Results Publications
2021-04-17 13:11:00 KRT8 and KRT19, associated with EMT, are hypomethylated and overexpressed in lung adenocarcinoma and link to unfavorable prognosis. 32519739
2020-10-31 13:14:00 Keratin 8 Mutations Were Associated With Susceptibility to Chronic Hepatitis B and Related Progression. 31515557
2020-09-12 16:03:00 Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. 32678092
2020-06-06 12:28:00 Using a site-specific mutation assay, we identified K8-Lys108 and K18-Lys187/426 as acetylation sites, and K8-Arg47 and K18-Arg55 as methylation sites. Keratin mutation (Arg-to-Lys/Ala) at the methylation sites, but not the acetylation sites, led to decreased stability of the keratin protein. 31199680
2019-11-30 12:55:00 Results identified self-antigens, Keratin 8, provoking a self-reactive T cell response suggesting its involvement in the immune-inflammatory mechanism of coronary artery disease. 30811493

名称对应

Type IDs
Synonymous CARD2, CK-8, CK8, CYK8, K2C8, K8, KO
Gene
UniProtKB-ID: K2C8_HUMAN, Q7L4M3_HUMAN
UniprotKB: P05787, Q7L4M3
UniParc: UPI000006CFE7, UPI0000161B3E, UPI0001892789
EMBL: AK222941, M34482, U76549, X74981, BC008200, M26512, BC063513, AK290938, BC075839, BC073760, M34225, X98614, AK310257, AC107016, X74929, CH471054, AK315826, X12882, BC000654
Ensembl: ENSG00000170421
KO: hsa:3856
Nucleutide sequences
EMBL-CDS: CAA52916.1, CAA31376.1, AAA35763.1, AAH75839.1, AAA51542.1, BAF98717.1, EAW96653.1, BAF83627.1, AAA35748.1, CAA52882.1, AAH73760.1, BAD96661.1, AAH00654.3, AAB18966.1, AAH63513.2, CAA67203.1, AAH08200.1
Ensembl_TRS: ENST00000293308, ENST00000546897, ENST00000552551, ENST00000552150
Protein sequencees
Ensembl_PRO: ENSP00000449404, ENSP00000447566, ENSP00000293308, ENSP00000447402
RefSeq: NP_001243211.1, NP_001243222.1, NP_002264.1
Others
UniRef100: UniRef100_P05787
UniRef90: UniRef90_P05787
UniRef50: UniRef50_P05787
UniGene: Hs.533782, Hs.708445
CCDS: CCDS8841.1, CCDS58234.1

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