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1757 SARDH

1757

SARDH

sarcosine dehydrogenase

protein-coding

Homo sapiens

基因描述

Type Description
Definition sarcosine dehydrogenase

研究结论

Date Results Publications
2020-02-29 11:01:00 SARDH methylation was found to be a significant prognostic factor for recurrencefree survival in renal cell carcinoma patients showing statistical independence from the clinical prognosticators, grade, stage and state of metastasis. 31545450
2019-11-09 11:25:00 Data first reported a deleterious c.551C>T mutation in SARDH in sporadic colorectal cancer (sCRC). SARDH was identified as a novel tumor suppressor gene and was abnormally decreased in sCRC at both the transcriptional and the translational level. SARDH overexpression inhibited the proliferation, migration, and invasion of CRC cell lines, whereas its depletion improved these processes. 30693981
2016-12-24 10:15:00 The SNPs rs2797840 and rs2073817 in SARDH may serve as an indicator for the occurrence of neural tube defects in the Chinese Han population, and rs2797840 may also be an indicator for folate content of brain. 27001897
2015-10-24 11:31:00 Expression of sarcosine metabolism-related proteins differed between ILC [invasive lobular carcinoma] and IDC [invasive ductal carcinoma]. 25837163
2014-01-04 12:39:00 SARDH and TMEFF2 cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. 23824605

名称对应

Type IDs
Synonymous BPR-2, DMGDHL1, SAR, SARD, SDH
Gene
UniProtKB-ID: SARDH_HUMAN, A8K596_HUMAN
UniprotKB: Q9UL12, A8K596
UniParc: UPI00017A796B, UPI000006F076, UPI00015DA785
EMBL: AF140737, AF095735, AF140730, AF140726, AF140744, AF140740, AF140738, AF129265, AL590710, AF140735, AK291211, BC136363, BC136364, AF140741, AF140736, AF140727, AF140745, CH471090, AF140731, AF140728, AF140732, AK298348, AF140734, AF140729, BC144035, AF162428, AK316494, AL365494, AF140739, AF140742, AF140743, AF140733
Ensembl: ENSG00000123453
KO: hsa:1757
Nucleutide sequences
EMBL-CDS: BAH14865.1, EAW88103.1, AAD43585.1, AAI44036.1, AAI36364.1, AAD32214.1, AAD53398.2, AAD33412.1, AAI36365.1, BAG60594.1, BAF83900.1
Ensembl_TRS: ENST00000439388, ENST00000371872
Protein sequencees
Ensembl_PRO: ENSP00000360938, ENSP00000403084
RefSeq: NP_001128179.1, XP_016869857.1, XP_016869856.1, NP_009032.2
Others
UniRef100: UniRef100_Q9UL12, UniRef100_A8K596
UniRef90: UniRef90_Q9UL12
UniRef50: UniRef50_Q9UL12
UniGene: Hs.198003
CCDS: CCDS6978.1

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