| Type | Description |
|---|---|
| Definition | DNA primase subunit 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-01 11:49:00 | Study results show that although human DNA primase C-terminal domain (p58C) can be stabilized in different conformations in the crystalline state, in solution there is effectively no difference in the structure and functional properties of p58C constructs of different lengths. | 30562384 |
| 2016-08-06 10:52:00 | Data suggest that PRIM1-p58,C-terminal domain stays bound to initiating NTP and 3prime-overhang DNA during whole cycle of RNA primer synthesis; meanwhile, PRIM1-p49 slides along DNA template toward 5prime-end with PRIM1-p58,N-terminal domain attached. | 26710848 |
| 2015-05-16 10:08:00 | Data indicate that the conformational changes in primase are necessary to accomplish the initiation and then elongation of RNA synthesis. | 25550159 |
| 2015-02-21 10:17:00 | the N-terminal domain of the large subunit of primase (p58N) directly interacts with the C-terminal domain of the catalytic subunit of polalpha (p180C) | 24962573 |
| 2012-10-13 10:09:00 | PRIM2 gene is not imprinted in the placenta. | 22437878 |
| Type | IDs |
|---|---|
| Synonymous | PRIM2A, p58 |
| Gene |
UniProtKB-ID:
PRI2_HUMAN,
A0A024RD43_HUMAN
UniprotKB:
P49643,
A0A024RD43
UniParc:
UPI000006FBC4,
UPI0000232A3A
EMBL:
CH471081,
BC064931,
X74331,
BC017833,
AL121975,
AL162579
Ensembl:
ENSG00000146143
KO:
hsa:5558
|
| Nucleutide sequences |
EMBL-CDS:
CAA52378.1,
AAH64931.1,
AAH17833.1,
EAX04481.1,
EAX04483.1
Gene_ORFName:
hCG_17136
Ensembl_TRS:
ENST00000615550,
ENST00000370687,
ENST00000274891
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000485304,
ENSP00000483201,
ENSP00000484105
RefSeq:
NP_000938.2,
XP_016866494.1,
XP_016866495.1,
XP_011513033.1,
XP_024302251.1,
NP_001269416.1,
NP_001269417.1,
XP_016866493.1
|
| Others |
UniRef100:
UniRef100_A0A024RD43,
UniRef100_P49643
UniRef90:
UniRef90_A0A024RD43,
UniRef90_P49643
UniRef50:
UniRef50_P49643,
UniRef50_B8JIP3
UniGene:
Hs.654580
CCDS:
CCDS75477.1,
CCDS75476.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 33060197 |
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science David E Gordon , Joseph Hiatt , Mehdi Bouhaddou , Veronica V Rezelj , Svenja Ulferts , Hannes Braberg , Alexander S Jureka , Kirsten Obernier , Jeffrey Z Guo , Jyoti Batra , Robyn M Kaake , Andrew R Weckstein , Tristan W Owens , Meghna Gupta , Sergei Pourmal , Erron W Titus , Merve Cakir , Margaret Soucheray , Michael McGregor , Zeynep Cakir , Gwendolyn Jang , Matthew J O'Meara , Tia A Tummino , Ziyang Zhang , Helene Foussard , Ajda Rojc , Yuan Zhou , Dmitry Kuchenov , Ruth Hüttenhain , Jiewei Xu , Manon Eckhardt , Danielle L Swaney , Jacqueline M Fabius , Manisha Ummadi , Beril Tutuncuoglu , Ujjwal Rathore , Maya Modak , Paige Haas , Kelsey M Haas , Zun Zar Chi Naing , Ernst H Pulido , Ying Shi , Inigo Barrio-Hernandez , Danish Memon , Eirini Petsalaki , Alistair Dunham , Miguel Correa Marrero , David Burke , Cassandra Koh , Thomas Vallet , Jesus A Silvas , Caleigh M Azumaya , Christian Billesbølle , Axel F Brilot , Melody G Campbell , Amy Diallo , Miles Sasha Dickinson , Devan Diwanji , Nadia Herrera , Nick Hoppe , Huong T Kratochvil , Yanxin Liu , Gregory E Merz , Michelle Moritz , Henry C Nguyen , Carlos Nowotny , Cristina Puchades , Alexandrea N Rizo , Ursula Schulze-Gahmen , Amber M Smith , Ming Sun , Iris D Young , Jianhua Zhao , Daniel Asarnow , Justin Biel , Alisa Bowen , Julian R Braxton , Jen Chen , Cynthia M Chio , Un Seng Chio , Ishan Deshpande , Loan Doan , Bryan Faust , Sebastian Flores , Mingliang Jin , Kate Kim , Victor L Lam , Fei Li , Junrui Li , Yen-Li Li , Yang Li , Xi Liu , Megan Lo , Kyle E Lopez , Arthur A Melo , Frank R Moss , Phuong Nguyen , Joana Paulino , Komal Ishwar Pawar , Jessica K Peters , Thomas H Pospiech , Maliheh Safari , Smriti Sangwan , Kaitlin Schaefer , Paul V Thomas , Aye C Thwin , Raphael Trenker , Eric Tse , Tsz Kin Martin Tsui , Feng Wang , Natalie Whitis , Zanlin Yu , Kaihua Zhang , Yang Zhang , Fengbo Zhou , Daniel Saltzberg , QCRG Structural Biology Consortium , Anthony J Hodder , Amber S Shun-Shion , Daniel M Williams , Kris M White , Romel Rosales , Thomas Kehrer , Lisa Miorin , Elena Moreno , Arvind H Patel , Suzannah Rihn , Mir M Khalid , Albert Vallejo-Gracia , Parinaz Fozouni , Camille R Simoneau , Theodore L Roth , David Wu , Mohd Anisul Karim , Maya Ghoussaini , Ian Dunham , Francesco Berardi , Sebastian Weigang , Maxime Chazal , Jisoo Park , James Logue , Marisa McGrath , Stuart Weston , Robert Haupt , C James Hastie , Matthew Elliott , Fiona Brown , Kerry A Burness , Elaine Reid , Mark Dorward , Clare Johnson , Stuart G Wilkinson , Anna Geyer , Daniel M Giesel , Carla Baillie , Samantha Raggett , Hannah Leech , Rachel Toth , Nicola Goodman , Kathleen C Keough , Abigail L Lind , Zoonomia Consortium , Reyna J Klesh , Kafi R Hemphill , Jared Carlson-Stevermer , Jennifer Oki , Kevin Holden , Travis Maures , Katherine S Pollard , Andrej Sali , David A Agard , Yifan Cheng , James S Fraser , Adam Frost , Natalia Jura , Tanja Kortemme , Aashish Manglik , Daniel R Southworth , Robert M Stroud , Dario R Alessi , Paul Davies , Matthew B Frieman , Trey Ideker , Carmen Abate , Nolwenn Jouvenet , Georg Kochs , Brian Shoichet , Melanie Ott , Massimo Palmarini , Kevan M Shokat , Adolfo GarcÃa-Sastre , Jeremy A Rassen , Robert Grosse , Oren S Rosenberg , Kliment A Verba , Christopher F Basler , Marco Vignuzzi , Andrew A Peden , Pedro Beltrao , Nevan J Krogan |
2020-12-04 | - |
| 32814053 |
Cell Rep Christian Haenig , Nir Atias , Alexander K Taylor , Arnon Mazza , Martin H Schaefer , Jenny Russ , Sean-Patrick Riechers , Shushant Jain , Maura Coughlin , Jean-Fred Fontaine , Brian D Freibaum , Lydia Brusendorf , Martina Zenkner , Pablo Porras , Martin Stroedicke , Sigrid Schnoegl , Kristin Arnsburg , Annett Boeddrich , Lucia Pigazzini , Peter Heutink , J Paul Taylor , Janine Kirstein , Miguel A Andrade-Navarro , Roded Sharan , Erich E Wanker |
2020-08-18 | - |
| 32353859 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature David E Gordon , Gwendolyn M Jang , Mehdi Bouhaddou , Jiewei Xu , Kirsten Obernier , Kris M White , Matthew J O'Meara , Veronica V Rezelj , Jeffrey Z Guo , Danielle L Swaney , Tia A Tummino , Ruth Hüttenhain , Robyn M Kaake , Alicia L Richards , Beril Tutuncuoglu , Helene Foussard , Jyoti Batra , Kelsey Haas , Maya Modak , Minkyu Kim , Paige Haas , Benjamin J Polacco , Hannes Braberg , Jacqueline M Fabius , Manon Eckhardt , Margaret Soucheray , Melanie J Bennett , Merve Cakir , Michael J McGregor , Qiongyu Li , Bjoern Meyer , Ferdinand Roesch , Thomas Vallet , Alice Mac Kain , Lisa Miorin , Elena Moreno , Zun Zar Chi Naing , Yuan Zhou , Shiming Peng , Ying Shi , Ziyang Zhang , Wenqi Shen , Ilsa T Kirby , James E Melnyk , John S Chorba , Kevin Lou , Shizhong A Dai , Inigo Barrio-Hernandez , Danish Memon , Claudia Hernandez-Armenta , Jiankun Lyu , Christopher J P Mathy , Tina Perica , Kala Bharath Pilla , Sai J Ganesan , Daniel J Saltzberg , Ramachandran Rakesh , Xi Liu , Sara B Rosenthal , Lorenzo Calviello , Srivats Venkataramanan , Jose Liboy-Lugo , Yizhu Lin , Xi-Ping Huang , YongFeng Liu , Stephanie A Wankowicz , Markus Bohn , Maliheh Safari , Fatima S Ugur , Cassandra Koh , Nastaran Sadat Savar , Quang Dinh Tran , Djoshkun Shengjuler , Sabrina J Fletcher , Michael C O'Neal , Yiming Cai , Jason C J Chang , David J Broadhurst , Saker Klippsten , Phillip P Sharp , Nicole A Wenzell , Duygu Kuzuoglu-Ozturk , Hao-Yuan Wang , Raphael Trenker , Janet M Young , Devin A Cavero , Joseph Hiatt , Theodore L Roth , Ujjwal Rathore , Advait Subramanian , Julia Noack , Mathieu Hubert , Robert M Stroud , Alan D Frankel , Oren S Rosenberg , Kliment A Verba , David A Agard , Melanie Ott , Michael Emerman , Natalia Jura , Mark von Zastrow , Eric Verdin , Alan Ashworth , Olivier Schwartz , Christophe d'Enfert , Shaeri Mukherjee , Matt Jacobson , Harmit S Malik , Danica G Fujimori , Trey Ideker , Charles S Craik , Stephen N Floor , James S Fraser , John D Gross , Andrej Sali , Bryan L Roth , Davide Ruggero , Jack Taunton , Tanja Kortemme , Pedro Beltrao , Marco Vignuzzi , Adolfo GarcÃa-Sastre , Kevan M Shokat , Brian K Shoichet , Nevan J Krogan |
2020-07-01 | - |
| 32416067 |
Mol Cell Shaokun Shu , Hua-Jun Wu , Jennifer Y Ge , Rhamy Zeid , Isaac S Harris , Bojana JovanoviÄ , Katherine Murphy , Binbin Wang , Xintao Qiu , Jennifer E Endress , Jaime Reyes , Klothilda Lim , Alba Font-Tello , Sudeepa Syamala , Tengfei Xiao , Chandra Sekhar Reddy Chilamakuri , Evangelia K Papachristou , Clive D'Santos , Jayati Anand , Kunihiko Hinohara , Wei Li , Thomas O McDonald , Adrienne Luoma , Rebecca J Modiste , Quang-De Nguyen , Brittany Michel , Paloma Cejas , Cigall Kadoch , Jacob D Jaffe , Kai W Wucherpfennig , Jun Qi , X Shirley Liu , Henry Long , Myles Brown , Jason S Carroll , Joan S Brugge , James Bradner , Franziska Michor , Kornelia Polyak |
2020-06-18 | - |
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 31091453 |
Cell Rep Adnan Shami Shah , Alex G Batrouni , Dongsung Kim , Amith Punyala , Wendy Cao , Chun Han , Michael L Goldberg , Marcus B Smolka , Jeremy M Baskin |
2019-05-14 | - |
| 30890647 |
J. Cell. Sci. Tiina Viita , Salla Kyheröinen , Bina Prajapati , Jori Virtanen , Mikko J Frilander , Markku Varjosalo , Maria K Vartiainen |
2019-04-17 | - |
| 29955894 |
KAP1 facilitates reinstatement of heterochromatin after DNA replication. Nucleic Acids Res. Suk Min Jang , Annamaria Kauzlaric , Jean-Pierre Quivy , Julien Pontis , Benjamin Rauwel , Andrea Coluccio , Sandra Offner , Julien Duc , Priscilla Turelli , Geneviève Almouzni , Didier Trono |
2018-09-28 | - |
| 30033366 |
Mapping the Genetic Landscape of Human Cells. Cell Max A Horlbeck , Albert Xu , Min Wang , Neal K Bennett , Chong Y Park , Derek Bogdanoff , Britt Adamson , Eric D Chow , Martin Kampmann , Tim R Peterson , Ken Nakamura , Michael A Fischbach , Jonathan S Weissman , Luke A Gilbert |
2018-08-09 | - |
| 29467282 |
Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. Jan B Heidelberger , Andrea Voigt , Marina E Borisova , Giuseppe Petrosino , Stefanie Ruf , Sebastian A Wagner , Petra Beli |
2018-04-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员