| Type | Description |
|---|---|
| Definition | RB binding protein 5, histone lysine methyltransferase complex subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 11:29:00 | We used a hybrid methods approach to study the assembly and biochemical function of the minimally active MLL1 complex (MLL1, WDR5 and RbBP5)..We identified a new interaction site between the MLL1 SET domain and the WD40 beta-propeller domain of RbBP5, and demonstrate the susceptibility of the catalytic function of the complex to disruption of individual interaction sites. | 31400120 |
| 2019-12-14 10:50:00 | We identified an internal interaction between the WD40 propeller and the C-terminal distal region in RBBP5, which assisted the maintenance of the compact conformation of the MLL1 complex. We also discovered a vertebrate-specific motif in the C-terminal distal region of RBBP5 that contributed to nucleosome recognition and methylation of nucleosomes by the MLL1 complex. | 31544921 |
| 2019-07-20 11:19:00 | Our nuclear magnetic resonance binding data supports the hypothesis that in addition to the role of RbBP5 in catalytic activation, its beta-propeller domain is a platform for the recruitment of the MLL complexes to chromatin targets through its direct interaction with nucleic acids. | 29897600 |
| 2019-03-23 12:19:00 | RBBP5 plays an important role in the progression of hepatocellular carcinoma. | 30533424 |
| 2018-07-23 13:15:00 | Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage. | 26288249 |
| Type | IDs |
|---|---|
| Synonymous | RBQ3, SWD1 |
| Gene |
UniProtKB-ID:
RBBP5_HUMAN,
B4DLF8_HUMAN,
A0A024R9B5_HUMAN
UniprotKB:
Q15291,
B4DLF8,
A0A024R9B5
UniParc:
UPI00001A9CA5,
UPI00017A750C,
UPI000006D4E4
EMBL:
BC075059,
AL583832,
AK296978,
AK290137,
BC037284,
CH471067,
AC093422,
X85134,
BC053856,
BC075060
Ensembl:
ENSG00000117222
KO:
hsa:5929
|
| Nucleutide sequences |
EMBL-CDS:
EAW91537.1,
BAF82826.1,
EAW91538.1,
AAH37284.1,
AAH53856.1,
AAH75060.1,
CAA59446.1,
AAH75059.1,
BAG59520.1,
EAW91539.1
Gene_ORFName:
hCG_16408
Ensembl_TRS:
ENST00000367164,
ENST00000264515
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356132,
ENSP00000264515
RefSeq:
NP_001180201.1,
XP_011508135.1,
NP_005048.2,
NP_001180202.1
|
| Others |
UniRef100:
UniRef100_Q15291,
UniRef100_B4DLF8
UniRef90:
UniRef90_Q5R7E1,
UniRef90_Q15291
UniRef50:
UniRef50_A0A672L307,
UniRef50_Q15291
UniGene:
Hs.519230
CCDS:
CCDS30983.1,
CCDS53463.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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