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5929 RBBP5

5929

RBBP5

RB binding protein 5, histone lysine methyltransferase complex subunit

protein-coding

Homo sapiens

基因描述

Type Description
Definition RB binding protein 5, histone lysine methyltransferase complex subunit

研究结论

Date Results Publications
2019-12-14 11:29:00 We used a hybrid methods approach to study the assembly and biochemical function of the minimally active MLL1 complex (MLL1, WDR5 and RbBP5)..We identified a new interaction site between the MLL1 SET domain and the WD40 beta-propeller domain of RbBP5, and demonstrate the susceptibility of the catalytic function of the complex to disruption of individual interaction sites. 31400120
2019-12-14 10:50:00 We identified an internal interaction between the WD40 propeller and the C-terminal distal region in RBBP5, which assisted the maintenance of the compact conformation of the MLL1 complex. We also discovered a vertebrate-specific motif in the C-terminal distal region of RBBP5 that contributed to nucleosome recognition and methylation of nucleosomes by the MLL1 complex. 31544921
2019-07-20 11:19:00 Our nuclear magnetic resonance binding data supports the hypothesis that in addition to the role of RbBP5 in catalytic activation, its beta-propeller domain is a platform for the recruitment of the MLL complexes to chromatin targets through its direct interaction with nucleic acids. 29897600
2019-03-23 12:19:00 RBBP5 plays an important role in the progression of hepatocellular carcinoma. 30533424
2018-07-23 13:15:00 Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage. 26288249

名称对应

Type IDs
Synonymous RBQ3, SWD1
Gene
UniProtKB-ID: RBBP5_HUMAN, B4DLF8_HUMAN, A0A024R9B5_HUMAN
UniprotKB: Q15291, B4DLF8, A0A024R9B5
UniParc: UPI00001A9CA5, UPI00017A750C, UPI000006D4E4
EMBL: BC075059, AL583832, AK296978, AK290137, BC037284, CH471067, AC093422, X85134, BC053856, BC075060
Ensembl: ENSG00000117222
KO: hsa:5929
Nucleutide sequences
EMBL-CDS: EAW91537.1, BAF82826.1, EAW91538.1, AAH37284.1, AAH53856.1, AAH75060.1, CAA59446.1, AAH75059.1, BAG59520.1, EAW91539.1
Gene_ORFName: hCG_16408
Ensembl_TRS: ENST00000367164, ENST00000264515
Protein sequencees
Ensembl_PRO: ENSP00000356132, ENSP00000264515
RefSeq: NP_001180201.1, XP_011508135.1, NP_005048.2, NP_001180202.1
Others
UniRef100: UniRef100_Q15291, UniRef100_B4DLF8
UniRef90: UniRef90_Q5R7E1, UniRef90_Q15291
UniRef50: UniRef50_A0A672L307, UniRef50_Q15291
UniGene: Hs.519230
CCDS: CCDS30983.1, CCDS53463.1

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