| Type | Description |
|---|---|
| Definition | thioredoxin related transmembrane protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-28 10:52:00 | Data show that TMX1 expression is upregulated in melanoma cell lines and patient samples. TMX knockdown altered mitochondrial organization, enhanced bioenergetics, and elevated mitochondrial- and NOX4-derived The TMX-knockdown-induced oxidative stress suppressed melanoma proliferation, migration, and xenograft tumor growth by inhibiting NFAT1. TMX1 is associated with poor disease outcome. | 31304984 |
| 2018-12-22 12:01:00 | TMX1 selectively intervenes in clearance of membrane-tethered Degradation substrates. TMX1 preferentially acts on membrane-tethered folding-defective polypeptides essentially ignoring the same misfolded ectodomains, when not associated to the membrane. | 29932915 |
| 2017-06-03 10:55:00 | TMX1 increases mitochondrial ATP production and apoptosis progression. | 27502484 |
| 2016-08-06 11:23:00 | Here we show that TMX1, one of the few transmembrane members of the family, forms functional complexes with the ER lectin calnexin and preferentially intervenes during maturation of cysteine-containing, membrane-associated proteins | 26246604 |
| 2013-08-31 10:22:00 | We conclude that TMX plays a major role in host defense under the type of inflammatory conditions associated with oxidative stress. | 22924822 |
| Type | IDs |
|---|---|
| Synonymous | PDIA11, TMX, TXNDC, TXNDC1 |
| Gene |
UniProtKB-ID:
TMX1_HUMAN
UniprotKB:
Q9H3N1
UniParc:
UPI0000048EB4
EMBL:
AK075395,
CH471078,
AL591807,
BC036460,
AB048246,
AK312905,
AL080080,
AY358640,
BC056874
Ensembl:
ENSG00000139921
KO:
hsa:81542
|
| Nucleutide sequences |
EMBL-CDS:
BAG35751.1,
AAH56874.2,
EAW65678.1,
BAB20629.1,
BAC11593.1,
AAH36460.1,
CAB45700.2,
AAQ89003.1
Gene_ORFName:
UNQ235/PRO268,
PSEC0085
Ensembl_TRS:
ENST00000457354
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000393316
RefSeq:
NP_110382.3
|
| Others |
UniRef100:
UniRef100_Q9H3N1
UniRef90:
UniRef90_Q9H3N1
UniRef50:
UniRef50_Q9H3N1
UniGene:
Hs.125221
CCDS:
CCDS41953.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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