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7347 UCHL3

7347

UCHL3

ubiquitin C-terminal hydrolase L3

protein-coding

Homo sapiens

基因描述

Type Description
Definition ubiquitin C-terminal hydrolase L3

研究结论

Date Results Publications
2021-04-03 13:35:00 Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration. 32486284
2021-03-13 13:24:00 Deubiquitylase UCHL3 regulates bi-orientation and segregation of chromosomes during mitosis. 32738097
2020-04-18 11:52:00 Our results indicate that highly expressed UCHL3 enhances inflammation by stabilizing TRAF2, which in turn facilitates tumourigenesis in ovarian cancer, and that UCHL3 is a potential target for ovarian cancer patients with increased inflammation. 31477831
2019-11-16 12:36:00 UCH-L3 might play a role in epithelial ovarian cancer pathogenesis and progression 31642235
2019-11-09 13:04:00 Depletion of UCHL3 increases TDP1 ubiquitylation and turnover rate and sensitizes cells to TOP1 poisons. Overexpression of UCHL3, but not a catalytically inactive mutant, suppresses TDP1 ubiquitylation and turnover rate. 29898404

名称对应

Type IDs
Synonymous UCH-L3
Gene
UniProtKB-ID: UCHL3_HUMAN, A0A087WTB8_HUMAN, A0A140VJZ4_HUMAN
UniprotKB: P15374, A0A087WTB8, A0A140VJZ4
UniParc: UPI000004D00E, UPI00001FCEE6
EMBL: M30496, BC018125, CH471093, HM005534, AK313665, CR456855, BT019359, AL137244
Ensembl: ENSG00000118939
KO: hsa:7347
Nucleutide sequences
EMBL-CDS: CAG33136.1, BAG36417.1, AAV38166.1, EAW80542.1, AAH18125.1, AAA36791.1, EAW80545.1, AEE61131.1
Gene_ORFName: hCG_29571
Ensembl_TRS: ENST00000377595, ENST00000618773
Protein sequencees
Ensembl_PRO: ENSP00000366819, ENSP00000477746
RefSeq: XP_011533515.1, XP_016876216.1, NP_005993.1, XP_016876215.1, XP_011533516.1, NP_001257881.1, XP_016876214.1, XP_011533514.1
Others
UniRef100: UniRef100_A0A087WTB8, UniRef100_P15374
UniRef90: UniRef90_G1LY57, UniRef90_P15374
UniRef50: UniRef50_A0A337S3N7, UniRef50_P15374
UniGene: Hs.162241
CCDS: CCDS9453.1

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