| Type | Description |
|---|---|
| Definition | RRN3 homolog, RNA polymerase I transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 11:55:00 | Depletion of Ebp1 expression in primary colon cancer cells inhibits cell proliferation, colony forming, and invasion in vitro as well as tumor formation in vivo and enhances cell sensitivity to irradiation. We further demonstrated that Ebp1 interacts with TIF-90, a splice variant of transcription initiation factor IA (TIF-IA) of the RNA polymerase I complex. | 30793766 |
| 2019-08-03 10:37:00 | Specific stress stimuli of NF-kappaB induce degradation of a critical component of the PolI complex, TIF-IA. This degradation precedes activation of NF-kappaB and is associated with increased nucleolar size. | 29873780 |
| 2014-03-01 11:50:00 | These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA. | 24297901 |
| 2013-06-01 12:02:00 | DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription | 23393135 |
| 2011-12-03 10:26:00 | reveals the molecular basis of Rrn3-regulated Pol I initiation and cell growth | 21940764 |
| Type | IDs |
|---|---|
| Synonymous | A-270G1.2, TIFIA |
| Gene |
UniProtKB-ID:
RRN3_HUMAN,
F5H148_HUMAN,
B7ZB55_HUMAN
UniprotKB:
Q9NYV6,
F5H148,
B7ZB55
UniParc:
UPI00019153AB,
UPI0002064EB0,
UPI000006E1BF,
UPI00017A854E,
UPI00005B72DF,
UPI00017A8920
EMBL:
BC071868,
AF227156,
AJ272050,
CH471301,
BC132690,
AK303405,
AK304856,
AK316520,
BC104660,
AC139256,
BC132688,
AK314769,
AC243651
Ensembl:
ENSG00000085721,
ENSG00000278494
KO:
hsa:54700
|
| Nucleutide sequences |
EMBL-CDS:
AAI04661.1,
EAW54754.1,
AAH71868.1,
AAF66160.1,
CAC07955.1,
BAG37307.1,
AAI32691.1,
BAG64459.1,
AAI32689.1,
BAG65594.1,
BAH14891.1
Ensembl_TRS:
ENST00000632541,
ENST00000616334,
ENST00000327307,
ENST00000634151,
ENST00000564131,
ENST00000198767,
ENST00000631800,
ENST00000429751
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000198767,
ENSP00000318484,
ENSP00000480743,
ENSP00000488651,
ENSP00000454238,
ENSP00000487821,
ENSP00000487970,
ENSP00000402027
RefSeq:
NP_001287993.1,
NP_060897.3
|
| Others |
UniRef100:
UniRef100_F5H148,
UniRef100_Q9NYV6,
UniRef100_B7ZB55
UniRef90:
UniRef90_Q9NYV6
UniRef50:
UniRef50_Q9NYV6
UniGene:
Hs.460078
CCDS:
CCDS10559.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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