| Type | Description |
|---|---|
| Definition | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:56:00 | BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma. | 31988198 |
| 2020-06-06 13:34:00 | Authors engineered cells in which the 3'-->5' exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess their immediate roles in nuclear RNA biology. The loss of DIS3 has the greatest impact, causing the substantial accumulation of thousands of transcripts within 60 min. | 30840897 |
| 2020-02-08 10:18:00 | The germline variants in DIS3. | 30967618 |
| 2019-12-07 11:21:00 | We further demonstrate that polyQ-expanded huntingtin delays Dis3 degradation during heat stress and thus hinders chaperone mRNA stabilization. Our findings not only reveal a post-transcriptional negative feedback loop for maintaining proteostasis, but also uncover a mechanism that contributes to the impaired heat stress response in Huntington's disease | 31428776 |
| 2019-04-06 11:45:00 | DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers. | 29802118 |
| Type | IDs |
|---|---|
| Synonymous | 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p |
| Gene |
UniProtKB-ID:
RRP44_HUMAN,
G3V1J5_HUMAN
UniprotKB:
Q9Y2L1,
G3V1J5
UniParc:
UPI0000141B8E,
UPI0000EE5A88,
UPI0000141B79
EMBL:
AB023225,
AK314715,
AL391384,
BC056143,
CH471093,
AL138695,
AL080158,
AF330044,
AL832266
Ensembl:
ENSG00000083520
KO:
hsa:22894
|
| Nucleutide sequences |
EMBL-CDS:
AAH56143.1,
BAA76852.2,
AAL37479.1,
EAW80517.1,
CAH56266.1,
CAB45749.1,
BAG37259.1,
EAW80519.1
Gene_ORFName:
hCG_32200
Ensembl_TRS:
ENST00000377780,
ENST00000377767,
ENST00000545453
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000367011,
ENSP00000366997,
ENSP00000440058
RefSeq:
NP_001309277.1,
NP_055768.3,
NP_001121698.1,
NP_001309278.1
|
| Others |
UniRef100:
UniRef100_Q9Y2L1
UniRef90:
UniRef90_Q9Y2L1
UniRef50:
UniRef50_Q9Y2L1
UniGene:
Hs.744104
CCDS:
CCDS45057.1,
CCDS9447.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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