| Type | Description |
|---|---|
| Definition | adenosylhomocysteinase |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 11:03:00 | Inhibition of DJ-1 potently enhances the sensitivity of tumor cells to ferroptosis inducers both in vitro and in vivo. Metabolic analysis and metabolite rescue assay reveal that DJ-1 depletion inhibits the transsulfuration pathway by disrupting the formation of the S-adenosyl homocysteine hydrolase tetramer and impairing its activity. Study findings show that DJ-1 determines the response of cancer cells to ferroptosis. | 32144268 |
| 2019-06-22 15:09:00 | Data report that SAHH binds to DNMT1 during DNA replication. SAHH enhances DNMT1 activity, and its overexpression led to hypermethylation of the genome, whereas its inhibition resulted in hypomethylation of the genome. Hypermethylation leads to aberrant gene regulation. Results suggest that alteration of SAHH level affects global DNA methylation levels and gene expression. | 29758262 |
| 2018-09-22 11:46:00 | Results uncover a H19/SAHH circuit involving gene-methylation alterations by carcinogen BaP. | 29772428 |
| 2018-06-09 11:20:00 | We investigated previously assumed interaction with AHCY-like-1 protein (AHCYL1), a paralog of AHCY. Indeed, significant interaction between both proteins exists. Additionally, silencing AHCYL1 leads to moderate inhibition of nuclear export of endogenous AHCY. | 28647132 |
| 2018-01-20 10:08:00 | We have validated the vectors and confirmed self-association of AHCY, AHCYL1, and galectin-3. In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 interaction | 27455993 |
| Type | IDs |
|---|---|
| Synonymous | SAHH, adoHcyase |
| Gene |
UniProtKB-ID:
SAHH_HUMAN,
Q1RMG2_HUMAN,
A0A384MTQ3_HUMAN
UniprotKB:
P23526,
Q1RMG2,
A0A384MTQ3
UniParc:
UPI00001354F1,
UPI0000D5B8B4,
UPI0001A7AE45
EMBL:
BC114924,
CH471077,
AK300014,
M61832,
AK097610,
AK316180,
AL356299,
BT006697,
AK290422,
BC011606,
M61831,
BC010018,
GQ891428
Ensembl:
ENSG00000101444
KO:
hsa:191
|
| Nucleutide sequences |
EMBL-CDS:
EAW76279.1,
BAG53495.1,
EAW76280.1,
AAH11606.1,
AAA51681.1,
AAA51682.1,
AAP35343.1,
AAH10018.1,
BAF83111.1,
BAG61829.1,
AAI14925.1,
BAH14551.1,
ADO22290.1
Ensembl_TRS:
ENST00000538132,
ENST00000217426
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000217426,
ENSP00000442820
RefSeq:
NP_001309013.1,
NP_001309014.1,
XP_016883198.1,
XP_016883199.1,
NP_001349679.1,
XP_011526961.1,
XP_005260374.1,
XP_011526960.2,
NP_001155238.1,
NP_001309015.1,
NP_000678.1,
XP_011526959.2,
XP_011526958.2
|
| Others |
UniRef100:
UniRef100_P23526,
UniRef100_Q1RMG2
UniRef90:
UniRef90_P23526
UniRef50:
UniRef50_P23526
UniGene:
Hs.388004
CCDS:
CCDS13233.1,
CCDS54457.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员