| Type | Description |
|---|---|
| Definition | transcription factor AP-4 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-05 12:56:00 | The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression. | 31530880 |
| 2020-03-21 10:36:00 | TFAP4-66aa-uORF inhibited the TFAP4/LINC00520/miR-520f-3p feedback loop. | 31943575 |
| 2019-12-14 11:27:00 | TFAP4 promotes hepatocellular carcinoma invasion and metastasis by inducing epithelial-mesenchymal transition and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway. | 31281549 |
| 2019-08-24 12:18:00 | These results provide new insight into the mechanisms underlying hyperactivation of the Wnt/beta-catenin pathway in hepatocellular carcinoma, as well the oncogenic ability of TFAP4 to enhance the tumor-forming ability of hepatocellular carcinoma cells via its binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). | 30026867 |
| 2019-06-08 11:07:00 | TRIB2 suppresses cellular senescence through interaction with AP4 to down-regulate p21 expression. | 30541550 |
| Type | IDs |
|---|---|
| Synonymous | AP-4, bHLHc41 |
| Gene |
UniProtKB-ID:
TFAP4_HUMAN
UniprotKB:
Q01664
UniParc:
UPI00001368DA
EMBL:
S73885,
X57435,
BC010576,
AC004653
Ensembl:
ENSG00000090447
KO:
hsa:7023
|
| Nucleutide sequences |
EMBL-CDS:
AAC17116.1,
AAH10576.1,
AAB32235.1,
CAA40683.1
Ensembl_TRS:
ENST00000204517
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000204517
RefSeq:
NP_003214.1,
XP_011520937.1,
XP_011520935.1
|
| Others |
UniRef100:
UniRef100_Q01664
UniRef90:
UniRef90_Q01664
UniRef50:
UniRef50_Q01664
UniGene:
Hs.513305
CCDS:
CCDS10510.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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