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27297 CRCP

27297

CRCP

CGRP receptor component

protein-coding

Homo sapiens

基因描述

Type Description
Definition CGRP receptor component

研究结论

Date Results Publications
2020-03-21 10:39:00 both anti-CGRP and anti-CGRP receptor monoclonal antibodies (mABs) completed clinical development, and the first representatives of these 2 classes are available on the market. MABs are approved for prevention of migraine attacks in chronic or episodic migraine, involving long-term treatments. 31018157
2017-07-22 10:30:00 data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine 27155150
2017-05-27 11:24:00 CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways. 27566546
2014-12-06 12:01:00 In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed. 25015815
2012-06-23 11:13:00 This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level 22074408

名称对应

Type IDs
Synonymous CGRP-RCP, CGRPRCP, RCP, RCP9, RPC9
Gene
UniProtKB-ID: RPC9_HUMAN, A0A024RDL0_HUMAN
UniprotKB: O75575, A0A024RDL0
UniParc: UPI0000074384, UPI0000128406, UPI00004DF8F2, UPI00017A8864
EMBL: BP233211, AF073792, BC040107, AC068533, CH471140, BC105808, BX647867, U51134, AK303737, AK290553, AK311829
Ensembl: ENSG00000241258
KO: hsa:27297
Nucleutide sequences
EMBL-CDS: BAG34771.1, EAX07941.1, AAH40107.1, BAG64710.1, BAF83242.1, AAD05036.1, AAI05809.1, AAC25992.1, CAI46069.1, EAX07943.1
Gene_ORFName: hCG_18703
Ensembl_TRS: ENST00000431089, ENST00000398684, ENST00000395326, ENST00000338592
Protein sequencees
Ensembl_PRO: ENSP00000378736, ENSP00000340044, ENSP00000381674, ENSP00000388653
RefSeq: NP_001035737.1, NP_055293.1, NP_001135886.1, NP_001035738.1
Others
UniRef100: UniRef100_O75575
UniRef90: UniRef90_O75575
UniRef50: UniRef50_O75575
UniGene: Hs.300684
CCDS: CCDS55116.1, CCDS5532.1, CCDS47599.1, CCDS47600.1

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