| Type | Description |
|---|---|
| Definition | DNA topoisomerase III alpha |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 11:33:00 | Top3alpha is shown to be an essential component of the mitochondrial DNA replication machinery and as the first component of the mitochondrial DNA separation machinery. | 29290614 |
| 2015-02-28 11:07:00 | The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex. | 25200081 |
| 2014-12-20 11:02:00 | hTOP3alpha interacts with p53, regulates p53 and p21 expression, and contributes to the p53-mediated tumor suppression | 24526736 |
| 2014-02-08 10:32:00 | MPS1 protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III alpha-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis | 24108125 |
| 2013-06-01 11:58:00 | Study found a correlation between topoisomerase IIIalpha immunoexpression and oral squamous cell carcinoma (OSCC) cancer stem cell immunophenotypes. However, results did not show a prognostic significance of topoisomerases in OSCC> | 22672768 |
| Type | IDs |
|---|---|
| Synonymous | MGRISCE2, PEOB5, TOP3, ZGRF7 |
| Gene |
UniProtKB-ID:
TOP3A_HUMAN,
B4DSJ0_HUMAN
UniprotKB:
Q13472,
B4DSJ0
UniParc:
UPI00017A7B21,
UPI000002B59B,
UPI00017A7588,
UPI00001371A0
EMBL:
HQ205036,
AK299764,
HQ205033,
AK296437,
HQ205029,
HQ205037,
HQ205053,
HQ205032,
AK292926,
HQ205061,
HQ205030,
HQ205062,
HQ205056,
HQ205039,
HQ205028,
HQ205042,
HQ205048,
HQ205055,
HQ205065,
HQ205026,
CH471196,
HQ205044,
HQ205051,
HQ205040,
HQ205049,
HQ205038,
HQ205064,
HQ205041,
HQ205060,
HQ205031,
HQ205059,
HQ205063,
HQ205043,
HQ205027,
HQ205054,
HQ205057,
HQ205047,
HQ205058,
HQ205045,
HQ205046,
AC127537,
HQ205050,
HQ205052,
U43431,
BC051748,
HQ205035,
HQ205034
Ensembl:
ENSG00000177302,
ENSG00000284238
KO:
hsa:7156
|
| Nucleutide sequences |
EMBL-CDS:
ADP90469.1,
AAB03694.1,
ADP90464.1,
ADP90488.1,
ADP90492.1,
ADP90477.1,
ADP90458.1,
ADP90483.1,
ADP90463.1,
ADP90493.1,
ADP90465.1,
ADP90467.1,
ADP90479.1,
ADP90480.1,
ADP90478.1,
ADP90462.1,
ADP90456.1,
AAH51748.1,
BAG59092.1,
ADP90487.1,
ADP90471.1,
EAW55646.1,
ADP90476.1,
ADP90489.1,
EAW55648.1,
ADP90486.1,
ADP90485.1,
ADP90473.1,
ADP90491.1,
ADP90459.1,
EAW55649.1,
ADP90455.1,
AAB03695.1,
ADP90460.1,
ADP90484.1,
ADP90457.1,
ADP90474.1,
ADP90481.1,
ADP90461.1,
ADP90470.1,
ADP90454.1,
ADP90466.1,
ADP90490.1,
ADP90482.1,
ADP90472.1,
ADP90468.1,
BAF85615.1,
ADP90475.1,
BAG61652.1
Ensembl_TRS:
ENST00000639065,
ENST00000321105,
ENST00000640743,
ENST00000638894,
ENST00000580095,
ENST00000542570
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000492229,
ENSP00000462790,
ENSP00000491689,
ENSP00000321636,
ENSP00000491260,
ENSP00000442336
RefSeq:
NP_004609.1,
NP_001307688.1,
XP_024306671.1,
XP_011522303.1
|
| Others |
UniRef100:
UniRef100_Q13472
UniRef90:
UniRef90_Q13472
UniRef50:
UniRef50_Q13472
UniGene:
Hs.592115
CCDS:
CCDS11194.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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Ensembl: {{protein.proteinEnsembl}} |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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