| Type | Description |
|---|---|
| Definition | DEAH-box helicase 36 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:11:00 | Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex. | 31586599 |
| 2019-06-29 11:18:00 | Considering that DHX36 targets, harboring G4s, preferentially localize in stress granules, and that DHX36 KO results in increased SG formation and protein kinase R (PKR/EIF2AK2) phosphorylation, we speculate that DHX36 is involved in resolution of rG4 induced cellular stress. | 31160600 |
| 2019-06-15 11:02:00 | Study demonstrated that unlike on G4-DNA, DHX36 displays ATP-independent unfolding of G4-RNA followed by ATP-dependent refolding, generating a highly asymmetric pattern of activity. DHX36 refolds G4-RNA in several steps, reflecting the discrete steps in forming the G4 structure. The ATP-dependent activity of DHX36 arises from the RNA tail rather than the G4. | 31015431 |
| 2019-03-09 12:20:00 | RNA G-quadruplex folding, controlled by the two DEAH-box helicases DHX36 and DHX9, impedes the scanning of the 43S preinitiation complex, promotes 80S ribosome formation within 5'-UTRs and consequently represses the translation of transcripts involved in key biological pathways. | 30591072 |
| 2019-02-16 12:08:00 | DHX36 has striking 3'-extension sequence preferences that differ for G4 disruption and dsDNA unwinding, most likely arising from differences in the rate-limiting step for the two activities. | 29269411 |
| Type | IDs |
|---|---|
| Synonymous | DDX36, G4R1, MLEL1, RHAU |
| Gene |
UniProtKB-ID:
DHX36_HUMAN
UniprotKB:
Q9H2U1
UniParc:
UPI000013ED25,
UPI00001AFA18,
UPI0000EE21F9
EMBL:
AJ577134,
AK314435,
AJ577133,
AF217190,
AC018452,
CH471052,
AC134026,
BC036035,
AB040921
Ensembl:
ENSG00000174953
KO:
hsa:170506
|
| Nucleutide sequences |
EMBL-CDS:
BAA96012.1,
BAG37047.1,
AAH36035.1,
EAW78761.1,
AAG36783.1,
CAE11802.1,
CAE11803.1
Ensembl_TRS:
ENST00000329463,
ENST00000496811,
ENST00000308361
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000330113,
ENSP00000417078,
ENSP00000309296
RefSeq:
NP_065916.2,
NP_001107869.1
|
| Others |
UniRef100:
UniRef100_Q9H2U1
UniRef90:
UniRef90_Q9H2U1
UniRef50:
UniRef50_Q9H2U1
UniGene:
Hs.446270
CCDS:
CCDS54657.1,
CCDS3171.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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