| Type | Description |
|---|---|
| Definition | apurinic/apyrimidinic endodeoxyribonuclease 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:33:00 | Genomic alterations and abnormal expression of APE2 in multiple cancers. | 32111912 |
| 2020-07-25 10:15:00 | Authors now show by immunoelectron microscopy that VAPB also localizes to the inner nuclear membrane (INM). Using a modified enhanced ascorbate peroxidase 2 (APEX2) approach with rapamycin-dependent targeting of the peroxidase to a protein of interest, we searched for proteins that are in close proximity to VAPB, particularly at the INM. | 31519755 |
| 2020-03-21 11:22:00 | we propose a two-step APE1/APE2-mediated mechanism for DNA single-strand breaks (SSBs) end resection that couples DNA damage response with SSB repair in a eukaryotic system. | 31828326 |
| 2019-11-23 11:00:00 | we describe the use of Clustered Regularly Interspaced Short Palindromic Repeats and an engineered ascorbate peroxidase 2 (APEX2) system to investigate local chromatin interactions (CAPLOCUS). We showed that with specific small-guide RNA targets, CAPLOCUS could efficiently identify both repetitive genomic regions and single-copy genomic locus with high resolution. | 30805613 |
| 2019-06-29 11:16:00 | Identified APEX2 and FEN1 as synthetic lethal genes with both BRCA1 and BRCA2 loss of function in tumor cell lines. | 30686591 |
| Type | IDs |
|---|---|
| Synonymous | APE2, APEXL2, XTH2, ZGRF2 |
| Gene |
UniProtKB-ID:
APEX2_HUMAN,
B4DWI9_HUMAN,
B7ZA71_HUMAN,
E5KN95_HUMAN
UniprotKB:
Q9UBZ4,
B4DWI9,
B7ZA71,
E5KN95
UniParc:
UPI0000EE771A,
UPI00017A808B,
UPI0000071F5B
EMBL:
BC002959,
AF119046,
HQ205215,
HQ205200,
HQ205218,
HQ205190,
HQ205225,
HQ205205,
HQ205219,
HQ205193,
HQ205217,
HQ205194,
HQ205211,
AY884244,
HQ205212,
HQ205223,
HQ205191,
HQ205198,
HQ205216,
HQ205197,
HQ205210,
HQ205224,
AJ011311,
HQ205192,
HQ205209,
HQ205204,
HQ205222,
HQ205188,
HQ205214,
HQ205201,
HQ205199,
AB021260,
AK316186,
AL020991,
HQ205213,
CH471154,
AK301555,
HQ205186,
AB049211,
HQ205202,
HQ205221,
HQ205206,
HQ205189,
HQ205207,
HQ205196,
HQ205208,
HQ205195,
HQ205187
Ensembl:
ENSG00000169188
KO:
hsa:27301
|
| Nucleutide sequences |
EMBL-CDS:
CAB45242.1,
BAA78422.1,
AAD43041.1,
AAW56941.1,
AAH02959.1,
BAB13764.1,
BAG63051.1,
BAH14557.1,
EAW93210.1,
ADP90676.1,
ADP90657.1,
ADP90680.1,
ADP90691.1,
ADP90674.1,
ADP90667.1,
ADP90681.1,
ADP90654.1,
ADP90662.1,
ADP90689.1,
ADP90664.1,
ADP90656.1,
ADP90690.1,
ADP90666.1,
ADP90686.1,
ADP90670.1,
ADP90683.1,
ADP90672.1,
EAW93209.1,
ADP90673.1,
ADP90659.1,
ADP90675.1,
ADP90655.1,
ADP90693.1,
ADP90677.1,
ADP90668.1,
ADP90692.1,
ADP90682.1,
ADP90685.1,
ADP90660.1,
ADP90661.1,
ADP90669.1,
ADP90679.1,
ADP90678.1,
ADP90663.1,
ADP90658.1,
ADP90687.1,
ADP90665.1,
ADP90684.1
Gene_ORFName:
hCG_18950,
hCG_18950
Ensembl_TRS:
ENST00000374987
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000364126
RefSeq:
NP_001258677.1,
NP_055296.2
|
| Others |
UniRef100:
UniRef100_Q9UBZ4,
UniRef100_B4DWI9
UniRef90:
UniRef90_Q9UBZ4,
UniRef90_B4DWI9
UniRef50:
UniRef50_Q9UBZ4,
UniRef50_B4DWI9
UniGene:
Hs.659558
CCDS:
CCDS14365.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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Ensembl: {{protein.proteinEnsembl}} |
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Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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