| Type | Description |
|---|---|
| Definition | protein phosphatase 2 scaffold subunit Aalpha |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:25:00 | Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1. | 32071079 |
| 2020-06-20 12:02:00 | R183W mutant of PPP2R1A, the gene encoding the PP2A Aalpha scaffolding subunit, failed to suppress tumor growth in vivo through activation of the MAPK pathway in RAS-mutant transformed cells. Cells expressing R183W were less sensitive to MEK inhibitors. Results demonstrate that the R183W mutation in PPP2R1A potentiates oncogenic signaling and reduces drug sensitivity of RAS-mutant cells to MEK inhibitors. | 31541192 |
| 2020-05-09 10:28:00 | Association of the rs10406151 C variant with AD risk appears to involve brain PPP2R1A gene expression alterations. | 31349112 |
| 2019-02-23 12:14:00 | In addition, 6 other cancer-associated genes (BRAF, NRAS, HRAS, ERK1, ERK2 and PTEN) were also analyzed. In total, four somatic mutations were identified in three out of 101 ovarian endometriotic lesions (4%, 4/101), including a KRAS p.G12V, a PPP2R1A p.S256F and two ARID1A nonsense mutations (p.Q403* and p.G1926*); while no mutations were identified in the remaining 7 genes (BRAF, NRAS, HRAS, ERK1, ERK2, PTEN and PIK3CA) | 29547736 |
| 2018-12-22 11:57:00 | PP2A controls mitotic exit through EG5 dephosphorylation. | 28487562 |
| Type | IDs |
|---|---|
| Synonymous | MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A |
| Gene |
UniProtKB-ID:
2AAA_HUMAN,
A8K7B7_HUMAN
UniprotKB:
P30153,
A8K7B7
UniParc:
UPI000006EB9C
EMBL:
AK315700,
J02902,
BC001537,
CR450340,
CH471135,
M31786,
AK291932,
HM005541
Ensembl:
ENSG00000105568
KO:
hsa:5518
|
| Nucleutide sequences |
EMBL-CDS:
CAG29336.1,
AAA35531.1,
AAH01537.1,
AAA36399.1,
AEE61138.1,
BAF84621.1,
EAW72066.1,
BAG38062.1
Gene_ORFName:
hCG_19686
Ensembl_TRS:
ENST00000322088
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000324804
RefSeq:
NP_055040.2,
NP_001350585.1
|
| Others |
UniRef100:
UniRef100_P30153
UniRef90:
UniRef90_P30153
UniRef50:
UniRef50_P30153
UniGene:
Hs.467192
CCDS:
CCDS12849.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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