| Type | Description |
|---|---|
| Definition | protein phosphatase 6 catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:24:00 | Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response. | 32474700 |
| 2019-10-19 11:38:00 | Data suggest that this Plk1-PP6 interaction generates a feedback loop that coordinates and reinforces the activities of Plk1 and Aurora A during mitotic entry and is terminated by the degradation of Plk1 during mitotic exit. Thus, a mechanism for the previously puzzling observation of the Plk1-dependent regulation of Aurora A has been identified. | 29764989 |
| 2018-07-03 11:46:00 | PP6 rapidly interacts with ASK3 in an osmolality-dependent manner, and it inactivates ASK3 to induce RVI and, thereby, cell survival under hyperosmotic stress. | 29539411 |
| 2017-10-28 11:00:00 | findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. | 29053956 |
| 2017-05-13 17:19:00 | Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac. | 27169767 |
| Type | IDs |
|---|---|
| Synonymous | PP6, PP6C |
| Gene |
UniProtKB-ID:
PPP6_HUMAN,
A0A024R861_HUMAN
UniprotKB:
O00743,
A0A024R861
UniParc:
UPI00005A1F48,
UPI00001320F6,
UPI000172E24D
EMBL:
AK295190,
KU178271,
BC006990,
CH471090,
AL445930,
BT019708,
AF035158,
AK299087,
X92972,
AK312332
Ensembl:
ENSG00000119414
KO:
hsa:5537
|
| Nucleutide sequences |
EMBL-CDS:
EAW87611.1,
BAH12945.1,
CAA63549.1,
AAH06990.1,
BAG35253.1,
BAH12005.1,
AAV38514.1,
AAD45400.2,
EAW87612.1,
ALQ33729.1
Gene_ORFName:
hCG_29657
Ensembl_TRS:
ENST00000415905,
ENST00000373547,
ENST00000451402
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000411744,
ENSP00000362648,
ENSP00000392147
RefSeq:
NP_001116841.1,
XP_011517149.1,
XP_024303375.1,
NP_002712.1,
NP_001116827.1
|
| Others |
UniRef100:
UniRef100_O00743
UniRef90:
UniRef90_O00743
UniRef50:
UniRef50_O00743
UniGene:
Hs.744091
CCDS:
CCDS6861.1,
CCDS48019.1,
CCDS48018.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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