| Type | Description |
|---|---|
| Definition | histamine N-methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 10:28:00 | Histamine N-methyltransferase plays a central role in the degradation of the neurotransmitter histamine. Leucine 208 is a critical amino acid residue to maintain the structural integrity of the protein. Replacements by other amino acid residues have profound effects on stability and catalytic activity. | 27769936 |
| 2018-09-22 11:02:00 | NHMT polymorphisms are not associated with Parkinson's disease, ALS and multiple system atrophy in Chinese population. | 29564728 |
| 2018-09-01 11:15:00 | miR-223 participates in the pathogenesis of atopic dermatitis through upregulating HNMT indirectly to degrade the excessive histamine. | 29506638 |
| 2018-06-23 11:57:00 | The C allele for the HNMT polymorphism was associated with a lower degree of disability due to migraine (OR, 10.0; 95% CI, 2.65-37.6). In contrast, presence of the T allele (in heterozygous individuals) was associated with higher degree of disability (OR, 37.1; 95% CI, 4.37-315.2) | 27130307 |
| 2018-03-10 11:47:00 | This study shown that eight linked SNPs (r(2) = 1) in the HNMT gene were associated with sedation according to the generalized linear model, adjusted for age, gender and BMI (false-discovery-rate-adjusted p = 0.013). | 28400155 |
| Type | IDs |
|---|---|
| Synonymous | HMT, HNMT-S1, HNMT-S2, MRT51 |
| Gene |
UniProtKB-ID:
HNMT_HUMAN,
B4DWC1_HUMAN
UniprotKB:
P50135,
B4DWC1
UniParc:
UPI0000072379,
UPI0000001BD1,
UPI00000747DD,
UPI00017A82AD
EMBL:
D16224,
AF523358,
AF523357,
U44109,
AC093674,
U44107,
U44108,
AK313804,
BC005907,
AF523360,
U44110,
AF523359,
CH471058,
AH012839,
BC020677,
AK301462,
U08092,
U44111,
AF523356,
U44106
Ensembl:
ENSG00000150540
KO:
hsa:3176
|
| Nucleutide sequences |
EMBL-CDS:
EAX11614.1,
BAG36540.1,
AAH20677.1,
AAN33017.1,
BAA03752.1,
AAA17423.1,
AAN33014.1,
AAY24212.1,
EAX11613.1,
AAH05907.1,
AAN33018.1,
EAX11612.1,
AAN33015.1,
AAN33016.1,
AAB18137.1,
AAP42155.1,
BAG62983.1
Ensembl_TRS:
ENST00000410115,
ENST00000280097,
ENST00000475675,
ENST00000280096,
ENST00000329366
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000280097,
ENSP00000386940,
ENSP00000280096,
ENSP00000419415,
ENSP00000333259
RefSeq:
XP_016859437.1,
NP_001019245.1,
NP_008826.1,
NP_001019246.1,
XP_011509366.1,
XP_016859438.1
|
| Others |
UniRef100:
UniRef100_B4DWC1,
UniRef100_P50135
UniRef90:
UniRef90_P50135,
UniRef90_B4DWC1
UniRef50:
UniRef50_P50135,
UniRef50_B4DWC1
UniGene:
Hs.42151
CCDS:
CCDS33297.1,
CCDS33296.1,
CCDS2181.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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