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7070 THY1

7070

THY1

Thy-1 cell surface antigen

protein-coding

Homo sapiens

基因描述

Type Description
Definition Thy-1 cell surface antigen

研究结论

Date Results Publications
2021-03-06 13:27:00 CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation. 33114405
2021-02-27 13:49:00 Transcription factor YY1 inhibits the expression of THY1 to promote interstitial pulmonary fibrosis by activating the HSF1/miR-214 axis. 32396525
2020-09-12 16:00:00 MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling. 31123165
2020-05-30 13:17:00 Neutrophils induced breast cancer epithelial-mesenchymal transition (EMT) via TIMP-1. Reciprocally, breast cancer cells undergoing EMT enhanced neutrophils' TIMP-1 secretion by CD90 in a cell-contact manner. In vivo, TIMP-1 neutralization or CD90 blockade significantly reduced metastasis. More importantly, TIMP-1 and CD90 were positively correlated in breast cancer and associated with poor prognosis of patients. 30482778
2020-04-25 10:36:00 We identified Thy-1 as a surface marker of cancer stem cells in ovarian cancer and further demonstrated increased proliferative and self-renewal capability in Thy-1 expressing cells that was reversible with Thy-1 knockdown. We were additionally able to validate these findings by identifying poorer clinical outcomes for women with ovarian cancer and high expression of Thy-1. 31735168

名称对应

Type IDs
Synonymous CD90, CDw90
Gene
UniProtKB-ID: THY1_HUMAN, B0YJA4_HUMAN
UniprotKB: P04216, B0YJA4
UniParc: UPI0000136F1F
EMBL: BC065559, AK090996, M11749, AL161958, CH471065, AF261093, S59749, EF445035, AK090644
Ensembl: ENSG00000154096
KO: hsa:7070
Nucleutide sequences
EMBL-CDS: CAB82306.1, AAB26353.2, AAG13904.1, AAH65559.1, AAA61180.1, EAW67490.1, ACA06081.1, BAG52259.1, EAW67488.1, BAG52205.1
Gene_ORFName: hCG_14965
Ensembl_TRS: ENST00000284240, ENST00000528522
Protein sequencees
Ensembl_PRO: ENSP00000284240, ENSP00000431301
RefSeq: NP_001358979.1, NP_001298091.1, NP_001298089.1, NP_006279.2
Others
UniRef100: UniRef100_P04216
UniRef90: UniRef90_P04216
UniRef50: UniRef50_P01831
UniGene: Hs.644697
CCDS: CCDS8424.1

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