| Type | Description |
|---|---|
| Definition | NPL4 homolog, ubiquitin recognition factor |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 16:01:00 | Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. | 33402676 |
| 2020-09-19 16:27:00 | Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma. | 32667929 |
| 2020-07-04 11:16:00 | Multisystem proteinopathy mutations in VCP/p97 increase NPLOC4-UFD1L binding and substrate processing. | 31623962 |
| 2018-05-12 11:36:00 | We demonstrate that WT p97 can unfold proteins and that this activity is dependent on the p97 adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiquitination, with branched chains providing maximal stimulation. | 28512218 |
| 2015-11-07 10:39:00 | The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100. | 26112410 |
| Type | IDs |
|---|---|
| Synonymous | NPL4 |
| Gene |
UniProtKB-ID:
NPL4_HUMAN,
A0A024R8R4_HUMAN
UniprotKB:
Q8TAT6,
A0A024R8R4
UniParc:
UPI0000070BDD,
UPI000034E5C8
EMBL:
AK000664,
AL834300,
AB040932,
AK023046,
CH471099,
AK023272,
BC025930
Ensembl:
ENSG00000182446
KO:
hsa:55666
|
| Nucleutide sequences |
EMBL-CDS:
BAB14499.1,
AAH25930.1,
CAD38971.1,
BAA91314.1,
BAA96023.1,
BAB14372.1,
EAW89662.1,
EAW89661.1
Gene_ORFName:
hCG_1811524
Ensembl_TRS:
ENST00000331134,
ENST00000374747
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363879,
ENSP00000331487
RefSeq:
NP_060391.2,
XP_011523282.1,
XP_011523284.1,
XP_011523281.1,
NP_001356627.1
|
| Others |
UniRef100:
UniRef100_Q8TAT6
UniRef90:
UniRef90_Q8TAT6
UniRef50:
UniRef50_Q8TAT6
UniGene:
Hs.464333
CCDS:
CCDS45812.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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