| Type | Description |
|---|---|
| Definition | purine rich element binding protein B |
| Date | Results | Publications |
|---|---|---|
| 2018-10-20 12:02:00 | Results showed that Purbeta ssDNA-binding activity was significantly increased in myeloid cells from AML patients suggesting that the enhanced ssDNA-binding activity of Purbeta in transformed myeloid cells may serve as a unique and measurable phenotypic trait for improving prognostic risk stratification in AML. | 28834593 |
| 2017-04-29 10:29:00 | site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta variants containing an R267A mutation exhibited reduced binding affinity for purine-ric... | 27064749 |
| 2014-07-26 10:56:00 | Suggest dynamic interplay between transcriptional activators Pur-alpha/Pur-beta and repressors in regulating SMalphaA gene output during myofibroblast differentiation. | 24446247 |
| 2010-04-07 21:39:00 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | 20201926 |
| 2010-01-21 00:00:00 | findings offer insights into mechanism, energetics, and sequence of Purbeta repressor binding to a biologically relevant, contractile phenotype-regulating cis-element while revealing the thermodynamic confines of Purbeta-mediated effects on DNA structure | 19496623 |
| Type | IDs |
|---|---|
| Synonymous | PURBETA |
| Gene |
UniProtKB-ID:
PURB_HUMAN
UniprotKB:
Q96QR8
UniParc:
UPI000006F6CE
EMBL:
CH236960,
AY039216,
BC101737,
BC101735,
AC004854,
CH471128
Ensembl:
ENSG00000146676
KO:
hsa:5814
|
| Nucleutide sequences |
EMBL-CDS:
EAW61073.1,
AAS00366.1,
AAK72462.1,
EAL23749.1,
AAI01738.1,
AAI01736.1
Ensembl_TRS:
ENST00000395699
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000379051
RefSeq:
NP_150093.1
|
| Others |
UniRef100:
UniRef100_Q96QR8
UniRef90:
UniRef90_O35295
UniRef50:
UniRef50_O35295
UniGene:
Hs.349150,
Hs.596321
CCDS:
CCDS5499.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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