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23770 FKBP8

23770

FKBP8

FKBP prolyl isomerase 8

protein-coding

Homo sapiens

基因描述

Type Description
Definition FKBP prolyl isomerase 8

研究结论

Date Results Publications
2020-10-03 12:56:00 FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions. 31908024
2020-02-15 10:54:00 This study identifies FK506 binding protein 8 (FKBP8) as a candidate interacting protein of VISA through the yeast two-hybrid technique. A novel function of FKBP8 in innate immunity antiviral signaling regulation was revealed in this study. 30267576
2019-05-18 11:50:00 Results demonstrated that FKBP8 physically interacts and co-localizes with SPP in endoplasmic reticulum, supporting that FKBP8 is a bona fide substrate of SPP. Also, the data support the involvement of inverse regulation of FKBP8 and mTOR signaling in SPP-enhanced tumorigenicity. 30348988
2019-03-16 10:11:00 FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the 30487393
2018-12-01 10:09:00 Cycling between the inactive GDP- and the active GTP-bound state modulates the backbone dynamics of a C-terminal truncated form, RhebDeltaCT, which is suggested to influence its interactions. We further investigated the interactions between RhebDeltaCT and the proposed Rheb-binding domain of the regulatory protein FKBP38. 29194576

名称对应

Type IDs
Synonymous FKBP38, FKBPr38
Gene
UniProtKB-ID: FKBP8_HUMAN, A0A024R7P2_HUMAN, B2R8G6_HUMAN
UniprotKB: Q14318, A0A024R7P2, B2R8G6
UniParc: UPI0001B3B591, UPI000020376E, UPI000000D918, UPI000013C7F9
EMBL: L37033, CH471106, AK222838, AY278607, BC009966, BX538124, AC005387, AY225339, BX647405, GQ372970, AK313363
Ensembl: ENSG00000105701
KO: hsa:23770
Nucleutide sequences
EMBL-CDS: AAB00102.1, AAH09966.1, AAC28753.1, CAD98028.1, AAO39020.1, ACU65096.1, BAD96558.1, EAW84709.1, AAQ84561.1, EAW84710.1, BAG36163.1
Gene_ORFName: hCG_1776905
Ensembl_TRS: ENST00000596558, ENST00000608443, ENST00000222308, ENST00000597960
Protein sequencees
Ensembl_PRO: ENSP00000222308, ENSP00000476767, ENSP00000471700, ENSP00000472302
RefSeq: NP_036313.3, NP_001295302.1
Others
UniRef100: UniRef100_Q14318, UniRef100_B2R8G6
UniRef90: UniRef90_Q14318, UniRef90_Q14318-2
UniRef50: UniRef50_Q14318
UniGene: Hs.173464
CCDS: CCDS32961.1, CCDS77266.1

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