| Type | Description |
|---|---|
| Definition | tryptophanyl-tRNA synthetase |
| Date | Results | Publications |
|---|---|---|
| 2019-10-26 12:17:00 | Data report a novel noncanonical function of WARS in antiviral defense. WARS is rapidly secreted in response to viral infection and primes the innate immune response by inducing the secretion of proinflammatory cytokines and type I IFNs, resulting in the inhibition of virus replication both in vitro and in vivo. These results suggest that WARS is a member of the antiviral innate immune response. | 30355684 |
| 2019-09-14 11:33:00 | Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus. | 30153112 |
| 2019-01-19 10:37:00 | Inhibition of human tryptophanyl-tRNA synthetase (TrpRS) expression by TrpRS-specific siRNAs decreased and overexpression of TrpRS increased Trp uptake into the cells | 29666190 |
| 2018-01-27 11:08:00 | Based on these results, secretion of full-length tryptophanyl-tRNA synthetase appears to work as a primary defence system against infection, acting before full activation of innate immunity. | 27748732 |
| 2017-11-04 10:41:00 | findings establish WARS as a gene whose mutations may cause distal hereditary motor neuropathy and alter canonical and non-canonical functions of tryptophanyl-tRNA synthetase. | 28369220 |
| Type | IDs |
|---|---|
| Synonymous | GAMMA-2, HMN9, IFI53, IFP53 |
| Gene |
UniProtKB-ID:
SYWC_HUMAN,
A0A024R6K8_HUMAN
UniprotKB:
P23381,
A0A024R6K8
UniParc:
UPI0000000E0E,
UPI00001FDB89
EMBL:
X67923,
S82905,
X67927,
AL157871,
BX248006,
M77804,
AK291141,
X67928,
CH471061,
AK056100,
GQ891525,
X67924,
X67925,
BC017489,
X67926,
X62570,
M61715,
BC095453,
X67920,
X59892,
X67922,
X67921
Ensembl:
ENSG00000140105
KO:
hsa:7453
|
| Nucleutide sequences |
EMBL-CDS:
AAA61298.1,
AAA67324.1,
BAG51626.1,
CAB94199.1,
AAH17489.1,
CAA44450.1,
AAH95453.1,
AAB39381.1,
CAA42545.1,
BAF83830.1,
CAB94198.1,
EAW81700.1,
CAD62335.1,
ADO22387.1,
EAW81701.1,
EAW81702.1,
EAW81703.1
Gene_ORFName:
hCG_25017
Ensembl_TRS:
ENST00000355338,
ENST00000392882,
ENST00000358655,
ENST00000556645,
ENST00000344102,
ENST00000557135
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000376620,
ENSP00000351481,
ENSP00000339485,
ENSP00000451460,
ENSP00000451887,
ENSP00000347495
RefSeq:
XP_024305475.1,
XP_016877118.1,
XP_016877116.1,
XP_011535438.1,
XP_005268101.1,
XP_006720312.1,
NP_776049.1,
NP_998811.1,
XP_024305474.1,
NP_998810.1,
XP_024305476.1,
XP_011535435.1,
NP_004175.2
|
| Others |
UniRef100:
UniRef100_P23381
UniRef90:
UniRef90_P23381
UniRef50:
UniRef50_P23381
UniGene:
Hs.497599
CCDS:
CCDS9961.1,
CCDS9960.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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