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27338 UBE2S

27338

UBE2S

ubiquitin conjugating enzyme E2 S

protein-coding

Homo sapiens

基因描述

Type Description
Definition ubiquitin conjugating enzyme E2 S

研究结论

Date Results Publications
2020-11-21 13:17:00 Ube2S regulates Wnt/beta-catenin signaling and promotes the progression of non-small cell lung cancer. 32038111
2020-10-31 13:19:00 Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. 32393902
2020-05-09 11:20:00 Data show that intramolecular transfer of ubiquitin from the catalytic cysteine to Lys+5 prevents the E1-mediated reloading of UBE2S with ubiquitin, thus conferring autoinhibition. Lys+5 ubiquitination of UBE2S is regulated in the context of the cell, with reduced levels during mitotic exit; however, this modification does not trigger proteasomal turnover of UBE2S. 31230944
2019-12-07 10:15:00 UBE2S mediates tumor progression via SOX6/beta-Catenin signaling in endometrial cancer 30690078
2019-11-09 12:41:00 Ube2s-promoted beta-Catenin accumulation partially released the dependence on exogenous molecules for the process of embryonic stem (ES) cell differentiation into mesoendoderm lineages. 29674637

名称对应

Type IDs
Synonymous E2-EPF, E2EPF, EPF5
Gene
UniProtKB-ID: UBE2S_HUMAN
UniprotKB: Q16763
UniParc: UPI000000122B
EMBL: M91670, BC007554, BC065364, AB062397, BC004236, AC020922
Ensembl: ENSG00000108106
KO: hsa:27338
Nucleutide sequences
EMBL-CDS: AAH07554.1, AAA58446.1, AAH65364.1, BAB93484.1, AAH04236.1
Gene_ORFName: OK/SW-cl.73
Ensembl_TRS: ENST00000264552
Protein sequencees
Ensembl_PRO: ENSP00000264552
RefSeq: XP_011525054.1, NP_055316.2
Others
UniRef100: UniRef100_Q16763
UniRef90: UniRef90_Q16763
UniRef50: UniRef50_Q16763
UniGene: Hs.396393
CCDS: CCDS33114.1

全选

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研究热度

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