| Type | Description |
|---|---|
| Definition | PCF11 cleavage and polyadenylation factor subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 13:34:00 | PCF11 is autoregulated through a conserved IPA site, the removal of which leads to global activation of PASs close to gene promotors. Therefore, PCF11 uses distinct mechanisms to regulate genes of different sizes, and its autoregulation maintains homeostasis of PAS usage in the cell. | 30840896 |
| 2019-07-20 12:17:00 | PCF11 selectively attenuates the expression of other transcriptional regulators by premature cleavage/polyadenylation and termination. | 30819644 |
| 2019-01-12 11:20:00 | Utilising extensive authors reveal the landscape and drivers of transcriptome 3'end-diversification, discovering PCF11 as critical regulator, directing alternative polyadenylation (APA) of hundreds of transcripts including a differentiation RNA-operon. | 30552333 |
| 2019-01-12 10:11:00 | We have reconstituted CF II as a heterodimer of hPcf11 and hClp1. The heterodimer is active in partially reconstituted cleavage reactions, whereas hClp1 by itself is not. Pcf11 moderately stimulates the RNA 5' kinase activity of hClp1; the kinase activity is dispensable for RNA cleavage | 30139799 |
| 2017-12-23 11:50:00 | WNK1 and the associated phosphorylation of the PCF11 CID act to promote transcript release from chromatin-associated Pol II, which in turn facilitates mRNA export to the cytoplasm | 29196535 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PCF11_HUMAN
UniprotKB:
O94913
UniParc:
UPI00001BB2B7
EMBL:
AF046935,
AB020631,
BC065384,
BC146778,
CH471076
Ensembl:
ENSG00000165494
KO:
hsa:51585
|
| Nucleutide sequences |
EMBL-CDS:
EAW75083.1,
BAA74847.1,
AAI46779.1,
AAC03107.1,
AAH65384.2
Ensembl_TRS:
ENST00000298281
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000298281
RefSeq:
NP_056969.2,
NP_001333343.1,
NP_001333344.1,
NP_001333342.1
|
| Others |
UniRef100:
UniRef100_O94913
UniRef90:
UniRef90_O94913
UniRef50:
UniRef50_O94913
UniGene:
Hs.128959,
Hs.731825
CCDS:
CCDS44689.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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