| Type | Description |
|---|---|
| Definition | ubiquitin protein ligase E3C |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:35:00 | VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. | 33637724 |
| 2020-10-24 14:04:00 | Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity. | 32039437 |
| 2020-07-11 12:56:00 | Findings indicate that miR-30a-5p inhibits ubiquitin Protein ligase E3C (UBE3C) expression by directly targeting its 3' untranslated regions (3'-UTR). | 27003255 |
| 2019-11-09 12:11:00 | Data suggest UBE3C-mediated AHNAK ubiquitination and degradation accompanied by subsequent blockage of p53 inhibition of stemness-related-gene transcription as a new posttranslational regulatory model describing maintenance of non-small-cell lung cancer (NSCLC) cell stemness. UBE3C knockdown increased p53 binding to the promoter regions inhibiting their transcription and preventing NSCLC tumorigenesis. | 30503554 |
| 2018-05-05 10:58:00 | miR-542-3p functioned as a tumor suppressor gene in regulating the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via targeting UBE3C. | 28666208 |
| Type | IDs |
|---|---|
| Synonymous | HECTH2 |
| Gene |
UniProtKB-ID:
UBE3C_HUMAN
UniprotKB:
Q15386
UniParc:
UPI000006D463,
UPI000020E72A,
UPI000006E986
EMBL:
D13635,
AC004975,
CH471149,
BC026241,
AC004898,
BC014029,
CH236954
Ensembl:
ENSG00000009335
KO:
hsa:9690
|
| Nucleutide sequences |
EMBL-CDS:
AAH26241.1,
BAA02799.2,
AAD51453.1,
AAH14029.1,
EAL23922.1,
EAX04568.1
Ensembl_TRS:
ENST00000389103,
ENST00000348165,
ENST00000611269
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000481584,
ENSP00000309198,
ENSP00000373755
RefSeq:
XP_016868307.1,
NP_055486.2,
XP_005249621.1
|
| Others |
UniRef100:
UniRef100_Q15386
UniRef90:
UniRef90_Q15386
UniRef50:
UniRef50_Q15386
UniGene:
Hs.118351
CCDS:
CCDS34789.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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