| Type | Description |
|---|---|
| Definition | seryl-tRNA synthetase |
| Date | Results | Publications |
|---|---|---|
| 2018-02-24 11:16:00 | Here, we report on mutations in two aminoacyl-tRNA synthetases that are associated with Intellectual disability (ID) in two unrelated Iranian families. In the first family, we identified a homozygous missense mutation (c.514G>A, p.Asp172Asn) in the cytoplasmic seryl-tRNA synthetase (SARS) gene | 28236339 |
| 2017-10-28 12:06:00 | Analyzed the ability of cytosolic SerRS to bind and act on tRNA(Ser), tRNA(Sec), and 10 mutant and chimeric constructs in which elements of tRNA(Ser) were transposed onto tRNA(Sec). We show that SerRS only subtly prefers tRNA(Ser) to tRNA(Sec), and that discrimination occurs at the level of the serylation reaction. | 28808125 |
| 2017-08-12 12:05:00 | Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS) to form a SerRS/YY1 complex which functions as a negative effector to regulate vegfa transcription through binding a distal segment of the vegfa promoter, while NFKB1 serves as a positive effector through outcompeting SerRS/YY1 for binding at the same distal segment. | 27913726 |
| 2016-04-30 10:21:00 | tRNA recognition mode of SerRS. | 26433229 |
| 2014-07-26 12:01:00 | Several data support that p.R402H mutation in SARS2 is a new cause of HUPRA syndrome. | 24034276 |
| Type | IDs |
|---|---|
| Synonymous | NEDMAS, SERRS, SERS |
| Gene |
UniProtKB-ID:
SYSC_HUMAN,
Q5T5C7_HUMAN,
Q0VGA5_HUMAN
UniprotKB:
P49591,
Q5T5C7,
Q0VGA5
UniParc:
UPI000013C9B6,
UPI000040E2B6,
UPI0000DBE1B1
EMBL:
BC111398,
BC009390,
X91257,
AL356389,
D49914,
BC000716,
CH471122,
AK312771
Ensembl:
ENSG00000031698
KO:
hsa:6301
|
| Nucleutide sequences |
EMBL-CDS:
AAH09390.1,
BAG35636.1,
AAH00716.1,
CAA62635.1,
BAA95602.1,
EAW56369.1,
AAI11399.1
Ensembl_TRS:
ENST00000234677,
ENST00000369923
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000234677,
ENSP00000358939
RefSeq:
NP_001317598.1,
NP_006504.2
|
| Others |
UniRef100:
UniRef100_Q0VGA5,
UniRef100_Q5T5C7,
UniRef100_P49591
UniRef90:
UniRef90_F6YEX7,
UniRef90_P26638,
UniRef90_P49591
UniRef50:
UniRef50_P49591,
UniRef50_P26638
UniGene:
Hs.531176
CCDS:
CCDS795.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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