| Type | Description |
|---|---|
| Definition | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:14:00 | The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation. | 33782411 |
| 2020-12-05 12:57:00 | High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance. | 32088725 |
| 2020-10-03 12:59:00 | Identification of MTHFD2 as a novel prognosis biomarker in esophageal carcinoma patients based on transcriptomic data and methylation profiling. | 32925794 |
| 2020-09-12 16:01:00 | Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy. | 31624245 |
| 2020-09-12 16:00:00 | MicroRNA-33a-5p suppresses colorectal cancer cell growth by inhibiting MTHFD2. | 31209892 |
| Type | IDs |
|---|---|
| Synonymous | NMDMC |
| Gene |
UniProtKB-ID:
MTDC_HUMAN
UniprotKB:
P13995
UniParc:
UPI0000208708,
UPI00001A3E6D
EMBL:
BC015062,
AK222826,
BC017054,
AC073263,
AK223041,
AK300035,
X16396,
BC001548,
CH471053
Ensembl:
ENSG00000065911
KO:
hsa:10797
|
| Nucleutide sequences |
EMBL-CDS:
BAD96761.1,
BAD96546.1,
EAW99672.1,
AAH15062.1,
EAW99671.1,
BAG61846.1,
AAX93061.1,
CAA34431.1,
AAH17054.2,
AAH01548.2
Ensembl_TRS:
ENST00000394053
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377617
RefSeq:
NP_006627.2,
XP_006711987.1
|
| Others |
UniRef100:
UniRef100_P13995
UniRef90:
UniRef90_P13995
UniRef50:
UniRef50_P13995
UniGene:
Hs.469030
CCDS:
CCDS1935.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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