| Type | Description |
|---|---|
| Definition | HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:45:00 | Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis. | 32537647 |
| 2021-03-13 13:21:00 | Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models. | 33116152 |
| 2021-03-13 13:19:00 | HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response. | 32457294 |
| 2021-02-20 13:31:00 | HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. | 33104527 |
| 2020-11-28 13:13:00 | The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma. | 32523091 |
| Type | IDs |
|---|---|
| Synonymous | ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1 |
| Gene |
UniProtKB-ID:
HUWE1_HUMAN,
A0A024R9W5_HUMAN
UniprotKB:
Q7Z6Z7,
A0A024R9W5
UniParc:
UPI000058E4FE,
UPI00004A0DAC,
UPI000058E4FD
EMBL:
AY772009,
BC063505,
AB002310,
CR456813,
AL162050,
CH471154,
AL592046,
DQ097177,
AB046798,
Z97054,
AY929612,
Z94044,
BC002602,
AF057569,
AF161390,
AB071605
Ensembl:
ENSG00000086758
KO:
hsa:10075
|
| Nucleutide sequences |
EMBL-CDS:
AAX24125.1,
AAH02602.2,
AAY98258.1,
CAG33094.1,
AAC62492.1,
BAB13404.1,
AAH63505.1,
BAC06833.1,
CAI39580.1,
CAB82393.1,
AAF28950.1,
AAV90838.1,
CAI42654.1,
BAA20771.3,
CAI42354.1,
EAW93166.1,
EAW93161.1
Gene_ORFName:
HSPC272,
hCG_2000770
Ensembl_TRS:
ENST00000262854,
ENST00000612484,
ENST00000342160
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000479451,
ENSP00000262854,
ENSP00000340648
RefSeq:
XP_005262022.1,
NP_113584.3,
XP_016884686.1,
XP_016884682.1,
XP_016884683.1,
XP_011529053.1,
XP_016884693.1,
XP_011529049.1,
XP_016884680.1,
XP_024308090.1,
XP_016884688.1,
XP_016884689.1,
XP_016884685.1,
XP_016884684.1,
XP_016884687.1,
XP_016884690.1,
XP_016884695.1,
XP_016884681.1,
XP_016884691.1,
XP_016884692.1
|
| Others |
UniRef100:
UniRef100_Q7Z6Z7
UniRef90:
UniRef90_Q7Z6Z7
UniRef50:
UniRef50_Q7Z6Z7
UniGene:
Hs.136905
CCDS:
CCDS35301.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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